Genetic Analysis of Complex Traits in Saccharomyces cerevisiae.
Defining the relationship between genotype and phenotype is a central challenge in biology. A powerful approach to this problem is to determine the genetic architecture and molecular basis of phenotypic differences among genetically diverse individuals. Saccharomyces cerevisiae is an important model system for such work. Current genetic mapping approaches for this species exploit high-throughput phenotyping and sequencing to facilitate the detection of a large fraction of the genomic loci that underlie trait variation among isolates. Once identified, several methods exist to determine the specific genes and genetic variants that underlie these loci and cause phenotypic variations. In this introduction, we provide a brief overview of research on complex traits in yeast and discuss different genetic mapping approaches applied to yeast studies.
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Related Subject Headings
- Sequence Analysis, DNA
- Saccharomyces cerevisiae
- Multifactorial Inheritance
- Molecular Biology
- High-Throughput Screening Assays
- Genetics, Microbial
- Chromosome Mapping
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
- 0306 Physical Chemistry (incl. Structural)
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Sequence Analysis, DNA
- Saccharomyces cerevisiae
- Multifactorial Inheritance
- Molecular Biology
- High-Throughput Screening Assays
- Genetics, Microbial
- Chromosome Mapping
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
- 0306 Physical Chemistry (incl. Structural)