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Self-reported depression in psoriasis is associated with subclinical vascular diseases.

Publication ,  Journal Article
Aberra, TM; Joshi, AA; Lerman, JB; Rodante, JA; Dahiya, AK; Teague, HL; Ng, Q; Silverman, JI; Sorokin, AV; Salahuddin, T; Lockshin, BN ...
Published in: Atherosclerosis
August 2016

Psoriasis is a chronic inflammatory disorder associated with vascular inflammation, measured by 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT), and an increased risk of myocardial infarction. Patients with psoriasis are also more likely to suffer from comorbid depression. Whether depression accelerates the development of subclinical atherosclerosis in psoriasis is unknown.Patients were selected from within a larger psoriasis cohort. Those who reported a history of depression (N = 36) on survey were matched by age and gender to patients who reported no history of psychiatric illness (N = 36). Target-to-background ratio from FDG PET/CT was used to assess aortic vascular inflammation and coronary CT angiography scans were analyzed to determine coronary plaque burden. Multivariable linear regression was performed to understand the effect of self-reported depression on vascular inflammation and coronary plaque burden after adjustment for Framingham risk (standardized β reported).In unadjusted analyses, vascular inflammation and coronary plaque burden were significantly increased in patients with self-reported depression as compared to patients with psoriasis alone. After adjustment for Framingham Risk Score, vascular inflammation (β = 0.26, p = 0.02), total plaque burden (β = 0.17, p = 0.03), and non-calcified burden (β = 0.17, p = 0.03) were associated with self-reported depression.Self-reported depression in psoriasis is associated with increased vascular inflammation and coronary plaque burden. Depression may play an important role in promoting subclinical atherosclerosis beyond traditional cardiovascular risk factors.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

ISSN

0021-9150

Publication Date

August 2016

Volume

251

Start / End Page

219 / 225

Related Subject Headings

  • Vascular Diseases
  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Self Report
  • Risk Factors
  • Psoriasis
  • Positron Emission Tomography Computed Tomography
  • Multivariate Analysis
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Aberra, T. M., Joshi, A. A., Lerman, J. B., Rodante, J. A., Dahiya, A. K., Teague, H. L., … Mehta, N. N. (2016). Self-reported depression in psoriasis is associated with subclinical vascular diseases. Atherosclerosis, 251, 219–225. https://doi.org/10.1016/j.atherosclerosis.2016.05.043
Aberra, Tsion M., Aditya A. Joshi, Joseph B. Lerman, Justin A. Rodante, Asha K. Dahiya, Heather L. Teague, Qimin Ng, et al. “Self-reported depression in psoriasis is associated with subclinical vascular diseases.Atherosclerosis 251 (August 2016): 219–25. https://doi.org/10.1016/j.atherosclerosis.2016.05.043.
Aberra TM, Joshi AA, Lerman JB, Rodante JA, Dahiya AK, Teague HL, et al. Self-reported depression in psoriasis is associated with subclinical vascular diseases. Atherosclerosis. 2016 Aug;251:219–25.
Aberra, Tsion M., et al. “Self-reported depression in psoriasis is associated with subclinical vascular diseases.Atherosclerosis, vol. 251, Aug. 2016, pp. 219–25. Epmc, doi:10.1016/j.atherosclerosis.2016.05.043.
Aberra TM, Joshi AA, Lerman JB, Rodante JA, Dahiya AK, Teague HL, Ng Q, Silverman JI, Sorokin AV, Salahuddin T, Lockshin BN, Ahlman MA, Playford MP, Chen MY, Gelfand JM, Mehta NN. Self-reported depression in psoriasis is associated with subclinical vascular diseases. Atherosclerosis. 2016 Aug;251:219–225.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

ISSN

0021-9150

Publication Date

August 2016

Volume

251

Start / End Page

219 / 225

Related Subject Headings

  • Vascular Diseases
  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Self Report
  • Risk Factors
  • Psoriasis
  • Positron Emission Tomography Computed Tomography
  • Multivariate Analysis
  • Middle Aged
  • Male