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Myeloid Cells in the Central Nervous System.

Publication ,  Journal Article
Herz, J; Filiano, AJ; Wiltbank, AT; Yogev, N; Kipnis, J
Published in: Immunity
June 20, 2017

The central nervous system (CNS) and its meningeal coverings accommodate a diverse myeloid compartment that includes parenchymal microglia and perivascular macrophages, as well as choroid plexus and meningeal macrophages, dendritic cells, and granulocytes. These myeloid populations enjoy an intimate relationship with the CNS, where they play an essential role in both health and disease. Although the importance of these cells is clearly recognized, their exact function in the CNS continues to be explored. Here, we review the subsets of myeloid cells that inhabit the parenchyma, meninges, and choroid plexus and discuss their roles in CNS homeostasis. We also discuss the role of these cells in various neurological pathologies, such as autoimmunity, mechanical injury, neurodegeneration, and infection. We highlight the neuroprotective nature of certain myeloid cells by emphasizing their therapeutic potential for the treatment of neurological conditions.

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Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

June 20, 2017

Volume

46

Issue

6

Start / End Page

943 / 956

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Neuroprotection
  • Neuroimmunomodulation
  • Neurodegenerative Diseases
  • Myeloid Cells
  • Meninges
  • Infections
  • Immunology
  • Humans
  • Choroid Plexus
 

Citation

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Herz, J., Filiano, A. J., Wiltbank, A. T., Yogev, N., & Kipnis, J. (2017). Myeloid Cells in the Central Nervous System. Immunity, 46(6), 943–956. https://doi.org/10.1016/j.immuni.2017.06.007
Herz, Jasmin, Anthony J. Filiano, Ashtyn T. Wiltbank, Nir Yogev, and Jonathan Kipnis. “Myeloid Cells in the Central Nervous System.Immunity 46, no. 6 (June 20, 2017): 943–56. https://doi.org/10.1016/j.immuni.2017.06.007.
Herz J, Filiano AJ, Wiltbank AT, Yogev N, Kipnis J. Myeloid Cells in the Central Nervous System. Immunity. 2017 Jun 20;46(6):943–56.
Herz, Jasmin, et al. “Myeloid Cells in the Central Nervous System.Immunity, vol. 46, no. 6, June 2017, pp. 943–56. Pubmed, doi:10.1016/j.immuni.2017.06.007.
Herz J, Filiano AJ, Wiltbank AT, Yogev N, Kipnis J. Myeloid Cells in the Central Nervous System. Immunity. 2017 Jun 20;46(6):943–956.
Journal cover image

Published In

Immunity

DOI

EISSN

1097-4180

Publication Date

June 20, 2017

Volume

46

Issue

6

Start / End Page

943 / 956

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Neuroprotection
  • Neuroimmunomodulation
  • Neurodegenerative Diseases
  • Myeloid Cells
  • Meninges
  • Infections
  • Immunology
  • Humans
  • Choroid Plexus