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Translational Immunotherapy of Brain Tumors

Immunotherapy Clinical Trials in Neuro-Oncology

Publication ,  Chapter
Khagi, S; Vlahovic, G
March 2, 2017

The treatment landscape of cancer is being quickly transformed by harnessing the power of the immune system. Its utilization has yielded remarkable responses in a wide range of malignancies and is being explored in a variety of carefully designed clinical trials, assessing both the clinical benefit and molecular biomarkers of response. Given these recent advances in systemic cancer management, focus has shifted to utilizing immunotherapy to hone in on malignant gliomas. A plethora of trials have already been devised and are currently in various stages of development and implementation. These trials investigate immunomodulatory techniques to prime, stimulate, and sustain a potent response against tumor-specific antigens. This chapter will examine these varied modalities of treatment and highlight the available data, both by appraising seminal immunotherapy clinical trials in systemic oncology, and moving into trials specifically focusing on malignant glioma. Furthermore, we will discuss criteria guiding clinical, radiographic, and immunologic parameters with respect to clinical trial development in neuro-oncology.

Duke Scholars

DOI

ISBN

9780128024201

Publication Date

March 2, 2017

Start / End Page

181 / 210
 

Citation

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Khagi, S., & Vlahovic, G. (2017). Immunotherapy Clinical Trials in Neuro-Oncology. In Translational Immunotherapy of Brain Tumors (pp. 181–210). https://doi.org/10.1016/B978-0-12-802420-1.00008-9
Khagi, S., and G. Vlahovic. “Immunotherapy Clinical Trials in Neuro-Oncology.” In Translational Immunotherapy of Brain Tumors, 181–210, 2017. https://doi.org/10.1016/B978-0-12-802420-1.00008-9.
Khagi S, Vlahovic G. Immunotherapy Clinical Trials in Neuro-Oncology. In: Translational Immunotherapy of Brain Tumors. 2017. p. 181–210.
Khagi, S., and G. Vlahovic. “Immunotherapy Clinical Trials in Neuro-Oncology.” Translational Immunotherapy of Brain Tumors, 2017, pp. 181–210. Scopus, doi:10.1016/B978-0-12-802420-1.00008-9.
Khagi S, Vlahovic G. Immunotherapy Clinical Trials in Neuro-Oncology. Translational Immunotherapy of Brain Tumors. 2017. p. 181–210.
Journal cover image

DOI

ISBN

9780128024201

Publication Date

March 2, 2017

Start / End Page

181 / 210