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Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration.

Publication ,  Journal Article
Fenwick, EK; Cheung, GCM; Gan, AT; Tan, G; Lee, SY; Wong, D; Yeo, I; Mathur, R; Wong, TY; Lamoureux, EL
Published in: Br J Ophthalmol
March 2018

AIM: To assess the change in vision-related quality of life (VRQoL) after treatment for neovascular age-related macular degeneration (nAMD) and factors influencing this change in an Asian population. METHODS: In this longitudinal study, 116 patients (mean age±SD=66.5±9.9 years; 59.5% male) who underwent treatment for nAMD were recruited from a tertiary eye centre in Singapore. Best-corrected visual acuity (BCVA) and the Impact of Vision Impairment (IVI) questionnaire were evaluated at baseline and month 12. We defined three categories of BCVA change in the treated eye: BCVA gain ≥2 lines; no change in BCVA; BCVA loss ≥2 lines. The main outcome measures were the Rasch-derived IVI Reading, Mobility, and Emotional Scores. Multivariable linear regression analyses assessed the influence of sociodemographic, clinical and treatment-related factors on change in VRQoL. RESULTS: Following treatment, mean treated-eye BCVA improved by almost 2 lines (-0.22±0.40 logMAR, p<0.001) and 43% (n=50) patients reported a gain in BCVA of ≥2 lines. Mean±SD scores for Reading, Mobility and Emotional demonstrated positive changes of 0.43±1.73, 0.45±1.54 and 0.66±1.6, respectively (p<0.001 for all). In multivariable models, a ≥2 line improvement in BCVA was independently associated with a 47% (β=0.20; CI 0.01 to 0.39) increase in Reading Scores, but was not independently associated with Mobility or Emotional Scores. CONCLUSION: Nearly half of patients undergoing treatment for nAMD reported a 2-line improvement in vision which was, in turn, associated with substantial positive increases in Reading Scores. Improvements in Mobility and Emotional Scores appear to be driven by factors other than visual acuity.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

March 2018

Volume

102

Issue

3

Start / End Page

377 / 382

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Tomography, Optical Coherence
  • Surveys and Questionnaires
  • Singapore
  • Sickness Impact Profile
  • Reading
  • Quality of Life
  • Prospective Studies
 

Citation

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Fenwick, E. K., Cheung, G. C. M., Gan, A. T., Tan, G., Lee, S. Y., Wong, D., … Lamoureux, E. L. (2018). Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration. Br J Ophthalmol, 102(3), 377–382. https://doi.org/10.1136/bjophthalmol-2017-310532
Fenwick, Eva K., Gemmy Chui Ming Cheung, Alfred Tl Gan, Gavin Tan, Shu Yen Lee, Doric Wong, Ian Yeo, Ranjana Mathur, Tien Y. Wong, and Ecosse L. Lamoureux. “Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration.Br J Ophthalmol 102, no. 3 (March 2018): 377–82. https://doi.org/10.1136/bjophthalmol-2017-310532.
Fenwick EK, Cheung GCM, Gan AT, Tan G, Lee SY, Wong D, et al. Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration. Br J Ophthalmol. 2018 Mar;102(3):377–82.
Fenwick, Eva K., et al. “Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration.Br J Ophthalmol, vol. 102, no. 3, Mar. 2018, pp. 377–82. Pubmed, doi:10.1136/bjophthalmol-2017-310532.
Fenwick EK, Cheung GCM, Gan AT, Tan G, Lee SY, Wong D, Yeo I, Mathur R, Wong TY, Lamoureux EL. Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration. Br J Ophthalmol. 2018 Mar;102(3):377–382.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

March 2018

Volume

102

Issue

3

Start / End Page

377 / 382

Location

England

Related Subject Headings

  • Wet Macular Degeneration
  • Visual Acuity
  • Vascular Endothelial Growth Factor A
  • Tomography, Optical Coherence
  • Surveys and Questionnaires
  • Singapore
  • Sickness Impact Profile
  • Reading
  • Quality of Life
  • Prospective Studies