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Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis.

Publication ,  Journal Article
Permpalung, N; Upala, S; Sanguankeo, A; Sornprom, S
Published in: Can J Gastroenterol Hepatol
2016

Objective. Clostridium difficile infection is a leading cause of nosocomial diarrhea in developed countries. Studies evaluating the associations of increased risk of community-acquired CDAD and the use of nonsteroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. We conducted a systematic review and meta-analysis to compare the odds of NSAID exposure in patients with CDAD versus patients without CDAD in both community-based and healthcare-associated settings. Methods. Relevant observational studies indexed in PubMed/MEDLINE and EMBASE up to February 2015 were analyzed and data were extracted from nine studies. Of these, eight studies were included in the meta-analysis. Results. A search of the databases resulted in 987 articles. The nine studies from which data were extracted involved over 39,000 subjects. The pooled odds ratio for history of NSAID use in participants with CDAD compared with controls was 1.41 (95% CI 1.06-1.87; p < 0.01), indicating a significant increased odds of CDAD among patients exposed to NSAIDs. Conclusions. To the best of our knowledge, this is the first study of its nature to demonstrate the association between the use of NSAIDs and increased risk of CDAD. Further studies to evaluate if any specific types of NSAIDs can increase the risk of CDAD are warranted.

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Published In

Can J Gastroenterol Hepatol

DOI

EISSN

2291-2797

Publication Date

2016

Volume

2016

Start / End Page

7431838

Location

Egypt

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Odds Ratio
  • Observational Studies as Topic
  • Male
  • Humans
  • Female
  • Enterocolitis, Pseudomembranous
  • Diarrhea
  • Clostridioides difficile
 

Citation

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Permpalung, N., Upala, S., Sanguankeo, A., & Sornprom, S. (2016). Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Can J Gastroenterol Hepatol, 2016, 7431838. https://doi.org/10.1155/2016/7431838
Permpalung, Nitipong, Sikarin Upala, Anawin Sanguankeo, and Suthanya Sornprom. “Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis.Can J Gastroenterol Hepatol 2016 (2016): 7431838. https://doi.org/10.1155/2016/7431838.
Permpalung N, Upala S, Sanguankeo A, Sornprom S. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Can J Gastroenterol Hepatol. 2016;2016:7431838.
Permpalung, Nitipong, et al. “Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis.Can J Gastroenterol Hepatol, vol. 2016, 2016, p. 7431838. Pubmed, doi:10.1155/2016/7431838.
Permpalung N, Upala S, Sanguankeo A, Sornprom S. Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. Can J Gastroenterol Hepatol. 2016;2016:7431838.

Published In

Can J Gastroenterol Hepatol

DOI

EISSN

2291-2797

Publication Date

2016

Volume

2016

Start / End Page

7431838

Location

Egypt

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Odds Ratio
  • Observational Studies as Topic
  • Male
  • Humans
  • Female
  • Enterocolitis, Pseudomembranous
  • Diarrhea
  • Clostridioides difficile