Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.
Publication
, Journal Article
Xie, D-L; Zheng, M-M; Zheng, Y; Gao, H; Zhang, J; Zhang, T; Guo, J-C; Yang, XF; Zhong, X-P; Lou, Y-L
Published in: PLoS One
2017
Vibrio vulnificus (V. vulnificus), a Gram-negative marine bacterium, can cause life-threatening primary septicemia, especially in patients with liver diseases. How V. vulnificus affects the liver and how it acts on macrophages are not well understood. In this report, we demonstrated that V. vulnificus infection causes a strong inflammatory response, marked expansion of liver-resident macrophages, and liver damage in mice. We demonstrated further that V. vulnificus activates mTOR in macrophages and inhibition of mTOR differentially regulates V. vulnificus induced inflammatory responses, suggesting the possibility of targeting mTOR as a strategy to modulate V. vulnificus induced inflammatory responses.
Duke Scholars
Published In
PLoS One
DOI
EISSN
1932-6203
Publication Date
2017
Volume
12
Issue
7
Start / End Page
e0181454
Location
United States
Related Subject Headings
- Vibrio vulnificus
- Vibrio Infections
- TOR Serine-Threonine Kinases
- Neutrophils
- NF-kappa B
- Mice, Inbred C57BL
- Mice
- Macrophages
- Liver
- Kupffer Cells
Citation
APA
Chicago
ICMJE
MLA
NLM
Xie, D.-L., Zheng, M.-M., Zheng, Y., Gao, H., Zhang, J., Zhang, T., … Lou, Y.-L. (2017). Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS One, 12(7), e0181454. https://doi.org/10.1371/journal.pone.0181454
Xie, Dan-Li, Meng-Meng Zheng, Yi Zheng, Hui Gao, Jie Zhang, Ting Zhang, Jian-Chun Guo, X Frank Yang, Xiao-Ping Zhong, and Yong-Liang Lou. “Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.” PLoS One 12, no. 7 (2017): e0181454. https://doi.org/10.1371/journal.pone.0181454.
Xie D-L, Zheng M-M, Zheng Y, Gao H, Zhang J, Zhang T, et al. Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS One. 2017;12(7):e0181454.
Xie, Dan-Li, et al. “Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages.” PLoS One, vol. 12, no. 7, 2017, p. e0181454. Pubmed, doi:10.1371/journal.pone.0181454.
Xie D-L, Zheng M-M, Zheng Y, Gao H, Zhang J, Zhang T, Guo J-C, Yang XF, Zhong X-P, Lou Y-L. Vibrio vulnificus induces mTOR activation and inflammatory responses in macrophages. PLoS One. 2017;12(7):e0181454.
Published In
PLoS One
DOI
EISSN
1932-6203
Publication Date
2017
Volume
12
Issue
7
Start / End Page
e0181454
Location
United States
Related Subject Headings
- Vibrio vulnificus
- Vibrio Infections
- TOR Serine-Threonine Kinases
- Neutrophils
- NF-kappa B
- Mice, Inbred C57BL
- Mice
- Macrophages
- Liver
- Kupffer Cells