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TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging

Publication ,  Conference
Bowsher, J; Yan, S; Roper, J; Giles, W; Yin, F
Published in: Medical Physics
January 1, 2012

Purpose: Radiation therapy beam guidance and modulation at treatment time could be substantially supported by onboard molecular and functional imaging capability. Currently there is very little range of technology available for this. Herein we propose and investigate a robotic multi‐pinhole SPECT system for this purpose. Methods: A 49‐pinhole system is designed with 7 pods and 7 pinholes per pod. Pod geometry is such that the full target region‐of‐interest (ROI) is within the FOV of all 7 pinholes for all pod distances exceeding a minimum distance from the ROI. Motion of the pods relative to one another can involve just 1 or 2 degrees of freedom per pod. Motion of the entire, composite 49‐pinhole system is provided by a robot. This design enables all 49 pinholes to view the full ROI throughout detector trajectories that can achieve sampling objectives, e.g. on line integrals measured, while also providing good resolution and sensitivity via close proximity to the ROI. The design is evaluated through computer simulation studies in which 7 and 10 mm diameter structures of 6‐to‐1 radiotracer uptake are added to the XCAT phantom. Results are compared to imaging with a compact parallel‐hole collimated detector, which is utilized as a reference for conventional SPECT imaging configurations. Results: For the 7 cm‐diameter target region of interest, the 49‐pinhole system shows markedly improved imaging as compared to the reference, parallel‐hole collimated detector. Most 7 mm and 10 mm diameter structures are readily visualized with 4 minute scans. Conclusions: In only a few minutes of scan time, the designed multi‐pinhole SPECT system can provide molecular and functional information about the target region as patients are in position for radiation therapy. This work is supported by NIH grant R21‐CA156390‐01A1. © 2012, American Association of Physicists in Medicine. All rights reserved.

Duke Scholars

Published In

Medical Physics

DOI

ISSN

0094-2405

Publication Date

January 1, 2012

Volume

39

Issue

6

Start / End Page

3887 / 3888

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bowsher, J., Yan, S., Roper, J., Giles, W., & Yin, F. (2012). TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging. In Medical Physics (Vol. 39, pp. 3887–3888). https://doi.org/10.1118/1.4735869
Bowsher, J., S. Yan, J. Roper, W. Giles, and F. Yin. “TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging.” In Medical Physics, 39:3887–88, 2012. https://doi.org/10.1118/1.4735869.
Bowsher J, Yan S, Roper J, Giles W, Yin F. TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging. In: Medical Physics. 2012. p. 3887–8.
Bowsher, J., et al. “TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging.” Medical Physics, vol. 39, no. 6, 2012, pp. 3887–88. Scopus, doi:10.1118/1.4735869.
Bowsher J, Yan S, Roper J, Giles W, Yin F. TU‐A‐BRA‐01: A Robotic Multi‐Pinhole SPECT System for Onboard and Other Region‐Of‐Interest Imaging. Medical Physics. 2012. p. 3887–3888.

Published In

Medical Physics

DOI

ISSN

0094-2405

Publication Date

January 1, 2012

Volume

39

Issue

6

Start / End Page

3887 / 3888

Related Subject Headings

  • Nuclear Medicine & Medical Imaging
  • 5105 Medical and biological physics
  • 4003 Biomedical engineering
  • 1112 Oncology and Carcinogenesis
  • 0903 Biomedical Engineering
  • 0299 Other Physical Sciences