Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay.
Publication
, Journal Article
Kahn, JA; Xu, J; Kapogiannis, BG; Sleasman, JW
Published in: J Acquir Immune Defic Syndr
June 1, 2017
We compared antibody responses of HIV-infected young women to the human papillomavirus (HPV) 6, 11, 16, and 18 vaccine using total immunoglobulin (Ig) G Luminex immunoassay (LIA) and competitive Luminex immunoassay (cLIA) assays. HPV18 seropositivity after HPV vaccination as measured with IgG LIA remained high (98%) 48 weeks after vaccination, in contrast with seropositivity as measured with cLIA (73%). Seropositivity rates at week 48 as measured by both IgG LIA and cLIA remained high for HPV6, 11, and 16 (93.5%-100%). These results suggest that the lower rate of seropositivity to HPV18 when cLIA vs. IgG LIA is used is a function of the assay and does not imply lower vaccine immunogenicity.
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Published In
J Acquir Immune Defic Syndr
DOI
EISSN
1944-7884
Publication Date
June 1, 2017
Volume
75
Issue
2
Start / End Page
241 / 245
Location
United States
Related Subject Headings
- Young Adult
- Virology
- Vaccination
- Papillomavirus Infections
- Immunoglobulin G
- Immunoassay
- Humans
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
- HIV Infections
- Female
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MLA
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Kahn, J. A., Xu, J., Kapogiannis, B. G., & Sleasman, J. W. (2017). Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay. J Acquir Immune Defic Syndr, 75(2), 241–245. https://doi.org/10.1097/QAI.0000000000001355
Kahn, Jessica A., Jiahong Xu, Bill G. Kapogiannis, and John W. Sleasman. “Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay.” J Acquir Immune Defic Syndr 75, no. 2 (June 1, 2017): 241–45. https://doi.org/10.1097/QAI.0000000000001355.
Kahn JA, Xu J, Kapogiannis BG, Sleasman JW. Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay. J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):241–5.
Kahn, Jessica A., et al. “Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay.” J Acquir Immune Defic Syndr, vol. 75, no. 2, June 2017, pp. 241–45. Pubmed, doi:10.1097/QAI.0000000000001355.
Kahn JA, Xu J, Kapogiannis BG, Sleasman JW. Brief Report: Antibody Responses to Quadrivalent HPV Vaccination in HIV-Infected Young Women as Measured by Total IgG and Competitive Luminex Immunoassay. J Acquir Immune Defic Syndr. 2017 Jun 1;75(2):241–245.
Published In
J Acquir Immune Defic Syndr
DOI
EISSN
1944-7884
Publication Date
June 1, 2017
Volume
75
Issue
2
Start / End Page
241 / 245
Location
United States
Related Subject Headings
- Young Adult
- Virology
- Vaccination
- Papillomavirus Infections
- Immunoglobulin G
- Immunoassay
- Humans
- Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18
- HIV Infections
- Female