Skip to main content

Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.

Publication ,  Journal Article
Fang, H; Yu, KJ; Gloschat, C; Yang, Z; Chiang, C-H; Zhao, J; Won, SM; Xu, S; Trumpis, M; Zhong, Y; Song, E; Han, SW; Xue, Y; Xu, D; Kay, M ...
Published in: Nature biomedical engineering
January 2017

Advanced capabilities in electrical recording are essential for the treatment of heart-rhythm diseases. The most advanced technologies use flexible integrated electronics; however, the penetration of biological fluids into the underlying electronics and any ensuing electrochemical reactions pose significant safety risks. Here, we show that an ultrathin, leakage-free, biocompatible dielectric layer can completely seal an underlying layer of flexible electronics while allowing for electrophysiological measurements through capacitive coupling between tissue and the electronics, and thus without the need for direct metal contact. The resulting current-leakage levels and operational lifetimes are, respectively, four orders of magnitude smaller and between two and three orders of magnitude longer than those of any other flexible-electronics technology. Systematic electrophysiological studies with normal, paced and arrhythmic conditions in Langendorff hearts highlight the capabilities of the capacitive-coupling approach. Our technology provides a realistic pathway towards the broad applicability of biocompatible, flexible electronic implants.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nature biomedical engineering

DOI

EISSN

2157-846X

ISSN

2157-846X

Publication Date

January 2017

Volume

1

Start / End Page

0038

Related Subject Headings

  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fang, H., Yu, K. J., Gloschat, C., Yang, Z., Chiang, C.-H., Zhao, J., … Rogers, J. A. (2017). Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology. Nature Biomedical Engineering, 1, 0038. https://doi.org/10.1038/s41551-017-0038
Fang, Hui, Ki Jun Yu, Christopher Gloschat, Zijian Yang, Chia-Han Chiang, Jianing Zhao, Sang Min Won, et al. “Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.Nature Biomedical Engineering 1 (January 2017): 0038. https://doi.org/10.1038/s41551-017-0038.
Fang H, Yu KJ, Gloschat C, Yang Z, Chiang C-H, Zhao J, et al. Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology. Nature biomedical engineering. 2017 Jan;1:0038.
Fang, Hui, et al. “Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology.Nature Biomedical Engineering, vol. 1, Jan. 2017, p. 0038. Epmc, doi:10.1038/s41551-017-0038.
Fang H, Yu KJ, Gloschat C, Yang Z, Chiang C-H, Zhao J, Won SM, Xu S, Trumpis M, Zhong Y, Song E, Han SW, Xue Y, Xu D, Cauwenberghs G, Kay M, Huang Y, Viventi J, Efimov IR, Rogers JA. Capacitively Coupled Arrays of Multiplexed Flexible Silicon Transistors for Long-Term Cardiac Electrophysiology. Nature biomedical engineering. 2017 Jan;1:0038.

Published In

Nature biomedical engineering

DOI

EISSN

2157-846X

ISSN

2157-846X

Publication Date

January 2017

Volume

1

Start / End Page

0038

Related Subject Headings

  • 4003 Biomedical engineering