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Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.

Publication ,  Journal Article
Böni, C; Thorne, JE; Spaide, RF; Ostheimer, TA; Sarraf, D; Levinson, RD; Goldstein, DA; Rifkin, LM; Vitale, AT; Jaffe, GJ; Holland, GN
Published in: Invest Ophthalmol Vis Sci
August 1, 2017

PURPOSE: The purpose of this study was to describe fundus autofluorescence (FAF) findings in eyes with birdshot chorioretinitis (BSCR) and to compare findings to demographic, medical, and clinical characteristics. METHODS: In this multicenter, prospective, cross-sectional study, 172 eyes (86 patients) with BSCR were investigated. Participants underwent a standardized evaluation including collection of demographic data, ophthalmic and treatment history, and ophthalmologic examination. Using a standardized protocol, hypo- and hyperautofluorescence in macular and extramacular regions and specific patterns of abnormal FAF could be scored for 167 eyes. Images were scored by two independent, masked graders. Measures of visual function included best-corrected visual acuity (BCVA), contrast sensitivity (CS), color vision, and Humphrey visual field mean deviation (HVF-MD). RESULTS: Any abnormal FAF finding was observed in 132 eyes (79.0%); macular abnormalities were observed in 84 eyes (49.1%). The most common findings were peripapillary confluent hypoautofluorescence (122 eyes [73.1%]); extramacular granular hypoautofluorescence (100 eyes [59.9%]); and macular granular hypoautofluorescence (67 eyes [40.1%]). Confluent hypoautofluorescence was related to longer median disease duration (8.7 years) than granular hypoautofluorescence (7.9 years) or hyperautofluorescence (5.6 years). Macular confluent hypoautofluorescence was associated with BCVA ≤20/25 (odds ratio [OR] = 7.83, P = 0.007), BCVA ≤20/50 (OR = 4.94, P = 0.002), and abnormal CS (OR = 4.56, P = 0.009). Presence of macular or extramacular hypoautofluorescence was related to HVF-MD ≤-3 dB (OR = 2.43, P = 0.01 and OR = 2.89, P = 0.003, respectively). CONCLUSIONS: In this large cohort, various FAF abnormalities were found, indicating that disorders of the retinal pigment epithelium are features of BSCR. Abnormal FAF is a marker of visual dysfunction in the disease.

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 1, 2017

Volume

58

Issue

10

Start / End Page

4015 / 4025

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Prospective Studies
  • Optical Imaging
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
 

Citation

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Böni, C., Thorne, J. E., Spaide, R. F., Ostheimer, T. A., Sarraf, D., Levinson, R. D., … Holland, G. N. (2017). Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis. Invest Ophthalmol Vis Sci, 58(10), 4015–4025. https://doi.org/10.1167/iovs.17-21897
Böni, Christian, Jennifer E. Thorne, Richard F. Spaide, Trucian A. Ostheimer, David Sarraf, Ralph D. Levinson, Debra A. Goldstein, et al. “Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.Invest Ophthalmol Vis Sci 58, no. 10 (August 1, 2017): 4015–25. https://doi.org/10.1167/iovs.17-21897.
Böni C, Thorne JE, Spaide RF, Ostheimer TA, Sarraf D, Levinson RD, et al. Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4015–25.
Böni, Christian, et al. “Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis.Invest Ophthalmol Vis Sci, vol. 58, no. 10, Aug. 2017, pp. 4015–25. Pubmed, doi:10.1167/iovs.17-21897.
Böni C, Thorne JE, Spaide RF, Ostheimer TA, Sarraf D, Levinson RD, Goldstein DA, Rifkin LM, Vitale AT, Jaffe GJ, Holland GN. Fundus Autofluorescence Findings in Eyes With Birdshot Chorioretinitis. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4015–4025.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 1, 2017

Volume

58

Issue

10

Start / End Page

4015 / 4025

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Pigment Epithelium
  • Prospective Studies
  • Optical Imaging
  • Ophthalmology & Optometry
  • Middle Aged
  • Male