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Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana.

Publication ,  Journal Article
Dotters-Katz, SK; Smid, MC; Manuck, TA; Metz, TD
Published in: J Matern Fetal Neonatal Med
December 2017

BACKGROUND: Limited data exist regarding the neonatal and neurodevelopmental outcomes of infants exposed to marijuana (MJ) in-utero, particularly among preterm infants. We hypothesized that MJ-exposed preterm infants would have worse neonatal and childhood developmental outcomes compared to MJ-unexposed infants. METHODS: Secondary analysis of multicenter randomized-controlled trial of antenatal magnesium sulfate for the prevention of cerebral palsy was conducted. Singleton nonanomalous infants delivered <35 weeks exposed to MJ in-utero were compared to MJ-unexposed. Primary neonatal outcome was death, grade 3/4 intraventricular hemorrhage, periventricular leukomalacia, bronchopulmonary dysplasia, and/or stage II/III necrotizing enterocolitis before discharge. Primary childhood outcome was death, moderate/severe cerebral palsy, or/and Bayley II Scales <70 at age 2. Backward-stepwise regression used to estimate odds of primary outcomes. RESULTS: 1867 infants met inclusion criteria; 135(7.2%) were MJ-exposed. There were no differences in neonatal (20% vs. 26%, p = 0.14) or childhood (26% vs. 21%, p = 0.21) outcomes in MJ-exposed infants compared to MJ-unexposed infants. In adjusted models, MJ-exposure was not associated with adverse neonatal outcomes (aOR 0.83 95% CI 0.47,1.44) or early childhood outcomes (aOR 1.47, 95% CI 0.97,2.23). CONCLUSIONS: Among infants born <35 weeks of gestation, MJ-exposure was not associated with adverse neonatal or childhood outcomes. Long-term follow-up studies are needed to assess later childhood neurodevelopmental outcomes following MJ-exposure.

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Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2017

Volume

30

Issue

24

Start / End Page

2933 / 2939

Location

England

Related Subject Headings

  • Risk Factors
  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Morbidity
  • Marijuana Abuse
  • Male
  • Magnesium Sulfate
  • Infant, Premature, Diseases
 

Citation

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Dotters-Katz, S. K., Smid, M. C., Manuck, T. A., & Metz, T. D. (2017). Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana. J Matern Fetal Neonatal Med, 30(24), 2933–2939. https://doi.org/10.1080/14767058.2016.1269165
Dotters-Katz, Sarah K., Marcela C. Smid, Tracy A. Manuck, and Torri D. Metz. “Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana.J Matern Fetal Neonatal Med 30, no. 24 (December 2017): 2933–39. https://doi.org/10.1080/14767058.2016.1269165.
Dotters-Katz SK, Smid MC, Manuck TA, Metz TD. Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana. J Matern Fetal Neonatal Med. 2017 Dec;30(24):2933–9.
Dotters-Katz, Sarah K., et al. “Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana.J Matern Fetal Neonatal Med, vol. 30, no. 24, Dec. 2017, pp. 2933–39. Pubmed, doi:10.1080/14767058.2016.1269165.
Dotters-Katz SK, Smid MC, Manuck TA, Metz TD. Risk of neonatal and childhood morbidity among preterm infants exposed to marijuana. J Matern Fetal Neonatal Med. 2017 Dec;30(24):2933–2939.

Published In

J Matern Fetal Neonatal Med

DOI

EISSN

1476-4954

Publication Date

December 2017

Volume

30

Issue

24

Start / End Page

2933 / 2939

Location

England

Related Subject Headings

  • Risk Factors
  • Prenatal Exposure Delayed Effects
  • Pregnancy Complications
  • Pregnancy
  • Obstetrics & Reproductive Medicine
  • Morbidity
  • Marijuana Abuse
  • Male
  • Magnesium Sulfate
  • Infant, Premature, Diseases