DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.
AIM: Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS: We quantified DNA methylation of nine imprinted gene differentially methylated regions by pyrosequencing in 296 cord blood DNA samples in a Mexican-American cohort. Fetal exposure was estimated by phthalate metabolite concentrations in maternal urine samples during pregnancy. RESULTS: Several differentially methylated regions of imprinted genes were associated with high molecular weight phthalates. The most consistent, positive, and false discovery rate significant associations were observed for MEG3. CONCLUSION: Phthalate exposure in utero may affect methylation status of imprinted genes in newborn children.
Duke Scholars
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- Sequence Analysis, DNA
- Pregnancy
- Phthalic Acids
- Mexican Americans
- Maternal Exposure
- Male
- Infant, Newborn
- Humans
- Genomic Imprinting
- Fetal Blood
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sequence Analysis, DNA
- Pregnancy
- Phthalic Acids
- Mexican Americans
- Maternal Exposure
- Male
- Infant, Newborn
- Humans
- Genomic Imprinting
- Fetal Blood