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DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.

Publication ,  Journal Article
Tindula, G; Murphy, SK; Grenier, C; Huang, Z; Huen, K; Escudero-Fung, M; Bradman, A; Eskenazi, B; Hoyo, C; Holland, N
Published in: Epigenomics
July 2018

AIM: Imprinted genes exhibit expression in a parent-of-origin-dependent manner and are critical for child development. Recent limited evidence suggests that prenatal exposure to phthalates, ubiquitous endocrine disruptors, can affect their epigenetic dysregulation. MATERIALS & METHODS: We quantified DNA methylation of nine imprinted gene differentially methylated regions by pyrosequencing in 296 cord blood DNA samples in a Mexican-American cohort. Fetal exposure was estimated by phthalate metabolite concentrations in maternal urine samples during pregnancy. RESULTS: Several differentially methylated regions of imprinted genes were associated with high molecular weight phthalates. The most consistent, positive, and false discovery rate significant associations were observed for MEG3. CONCLUSION: Phthalate exposure in utero may affect methylation status of imprinted genes in newborn children.

Duke Scholars

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Published In

Epigenomics

DOI

EISSN

1750-192X

Publication Date

July 2018

Volume

10

Issue

7

Start / End Page

1011 / 1026

Location

England

Related Subject Headings

  • Sequence Analysis, DNA
  • Pregnancy
  • Phthalic Acids
  • Mexican Americans
  • Maternal Exposure
  • Male
  • Infant, Newborn
  • Humans
  • Genomic Imprinting
  • Fetal Blood
 

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Tindula, G., Murphy, S. K., Grenier, C., Huang, Z., Huen, K., Escudero-Fung, M., … Holland, N. (2018). DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure. Epigenomics, 10(7), 1011–1026. https://doi.org/10.2217/epi-2017-0178
Tindula, Gwen, Susan K. Murphy, Carole Grenier, Zhiqing Huang, Karen Huen, Maria Escudero-Fung, Asa Bradman, Brenda Eskenazi, Cathrine Hoyo, and Nina Holland. “DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.Epigenomics 10, no. 7 (July 2018): 1011–26. https://doi.org/10.2217/epi-2017-0178.
Tindula G, Murphy SK, Grenier C, Huang Z, Huen K, Escudero-Fung M, et al. DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure. Epigenomics. 2018 Jul;10(7):1011–26.
Tindula, Gwen, et al. “DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure.Epigenomics, vol. 10, no. 7, July 2018, pp. 1011–26. Pubmed, doi:10.2217/epi-2017-0178.
Tindula G, Murphy SK, Grenier C, Huang Z, Huen K, Escudero-Fung M, Bradman A, Eskenazi B, Hoyo C, Holland N. DNA methylation of imprinted genes in Mexican-American newborn children with prenatal phthalate exposure. Epigenomics. 2018 Jul;10(7):1011–1026.
Journal cover image

Published In

Epigenomics

DOI

EISSN

1750-192X

Publication Date

July 2018

Volume

10

Issue

7

Start / End Page

1011 / 1026

Location

England

Related Subject Headings

  • Sequence Analysis, DNA
  • Pregnancy
  • Phthalic Acids
  • Mexican Americans
  • Maternal Exposure
  • Male
  • Infant, Newborn
  • Humans
  • Genomic Imprinting
  • Fetal Blood