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Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis.

Publication ,  Journal Article
Williamson, DM; Marrie, RA; Ashley-Koch, A; Satten, GA
Published in: Immunol Infect Dis
September 2013

This study was conducted to determine whether single nucleotide polymorphisms (SNPs) in nine genes (human leukocyte antigen (HLA), T cell receptor beta (TCA receptor β), tumor necrosis factor α (TNF α), tumor necrosis factor β (TNF β), apolipoprotein E (APOE), interleukin 7 receptor alpha chain (IL7RA) interleukin 2 receptor alpha chain (IL2RA) myelin basic protein (MBP) and vitamin D receptor (VDR)) associated with multiple sclerosis (MS) could be replicated in a population-based sample, and to determine if these associations are modified by presence of HLA DRB1*1501. DNA was available from 722 individuals (223 with MS and 499 controls) who participated in a population-based case-control study. Cases and controls were matched on ancestry, age, gender and geographic area. HLA DRB1*1501 risk allele (T) was confirmed in this population using a genotypic test, controlling for multiple comparisons. Examining the effect of each SNP in the presence or absence of the HLA DRB1*1501 risk allele identified significant associations with TNF α -1031 (rs1799964) among those without the HLA risk allele. No additional interactions were significant in a cases-only analysis. Our results indicate that an interaction between SNPs in TNF α and HLA DRB1*1501 may influence the risk of developing MS.

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Published In

Immunol Infect Dis

DOI

ISSN

2333-2719

Publication Date

September 2013

Volume

1

Issue

1

Start / End Page

10 / 17

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Williamson, D. M., Marrie, R. A., Ashley-Koch, A., & Satten, G. A. (2013). Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis. Immunol Infect Dis, 1(1), 10–17. https://doi.org/10.13189/iid.2013.010102
Williamson, Dhelia M., Ruth Ann Marrie, Allison Ashley-Koch, and Glen A. Satten. “Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis.Immunol Infect Dis 1, no. 1 (September 2013): 10–17. https://doi.org/10.13189/iid.2013.010102.
Williamson DM, Marrie RA, Ashley-Koch A, Satten GA. Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis. Immunol Infect Dis. 2013 Sep;1(1):10–7.
Williamson, Dhelia M., et al. “Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis.Immunol Infect Dis, vol. 1, no. 1, Sept. 2013, pp. 10–17. Pubmed, doi:10.13189/iid.2013.010102.
Williamson DM, Marrie RA, Ashley-Koch A, Satten GA. Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control Study of Multiple Sclerosis. Immunol Infect Dis. 2013 Sep;1(1):10–17.

Published In

Immunol Infect Dis

DOI

ISSN

2333-2719

Publication Date

September 2013

Volume

1

Issue

1

Start / End Page

10 / 17

Location

United States