Skip to main content

Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.

Publication ,  Journal Article
James, ML; Langefeld, CD; Sekar, P; Moomaw, CJ; Elkind, MSV; Worrall, BB; Sheth, KN; Martini, SR; Osborne, J; Woo, D; ERICH Investigators,
Published in: Neurology
September 5, 2017

OBJECTIVE: Because age affects hormonal production differently in women compared with men, we sought to define sex and age interactions across a multiracial/ethnic population after intracerebral hemorrhage (ICH) to uncover evidence that loss of gonadal hormone production would result in loss of the known neuroprotective effects of gonadal hormones. METHODS: Clinical and radiographic data from participants in the Ethnic/Racial Variations of Intracerebral Hemorrhage study and the Genetic and Environmental Risk Factors for Hemorrhagic Stroke study prior to December 2013 were used. Relationships among sex, age, and outcome after ICH in 616 non-Hispanic black, 590 Hispanic, and 868 non-Hispanic white participants were evaluated using multivariable logistic regression analysis. Poor outcome was defined as modified Rankin Scale score ≥3 at 90 days after ICH. RESULTS: Sex differences were found in multiple variables among the racial/ethnic groups, including age at onset, premorbid neurologic status, and neurologic outcome after ICH. Overall, no sex-age interaction effect was found for mortality (p = 0.183) or modified Rankin Scale score (p = 0.378) at 90 days after ICH. In racial/ethnic subgroups, only the non-Hispanic black cohort provided possible evidence of a sex-age interaction on 90-day modified Rankin Scale score (p = 0.003). CONCLUSION: Unlike in ischemic stroke, there was no evidence that patient sex modified the effect of age on 90-day outcomes after ICH in a large multiracial/ethnic population. Future studies should evaluate biological reasons for these differences between stroke subtypes. CLINICALTRIALSGOV IDENTIFIER: NCT01202864.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

September 5, 2017

Volume

89

Issue

10

Start / End Page

1011 / 1019

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Sex Factors
  • Severity of Illness Index
  • Prospective Studies
  • Ohio
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

APA
Chicago
ICMJE
MLA
NLM
James, M. L., Langefeld, C. D., Sekar, P., Moomaw, C. J., Elkind, M. S. V., Worrall, B. B., … ERICH Investigators, . (2017). Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology, 89(10), 1011–1019. https://doi.org/10.1212/WNL.0000000000004255
James, Michael L., Carl D. Langefeld, Padmini Sekar, Charles J. Moomaw, Mitchell S. V. Elkind, Bradford B. Worrall, Kevin N. Sheth, et al. “Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.Neurology 89, no. 10 (September 5, 2017): 1011–19. https://doi.org/10.1212/WNL.0000000000004255.
James ML, Langefeld CD, Sekar P, Moomaw CJ, Elkind MSV, Worrall BB, et al. Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology. 2017 Sep 5;89(10):1011–9.
James, Michael L., et al. “Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage.Neurology, vol. 89, no. 10, Sept. 2017, pp. 1011–19. Pubmed, doi:10.1212/WNL.0000000000004255.
James ML, Langefeld CD, Sekar P, Moomaw CJ, Elkind MSV, Worrall BB, Sheth KN, Martini SR, Osborne J, Woo D, ERICH Investigators. Assessment of the interaction of age and sex on 90-day outcome after intracerebral hemorrhage. Neurology. 2017 Sep 5;89(10):1011–1019.

Published In

Neurology

DOI

EISSN

1526-632X

Publication Date

September 5, 2017

Volume

89

Issue

10

Start / End Page

1011 / 1019

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Time Factors
  • Sex Factors
  • Severity of Illness Index
  • Prospective Studies
  • Ohio
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Logistic Models