Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.
Publication
, Journal Article
Battaglioli, G; Rosen, DR; Gospe, SM; Martin, DL
Published in: Neurology
July 25, 2000
Several aspects of pyridoxine-dependent seizure (PDS) suggest a mutation affecting glutamate decarboxylase (GAD) as a possible cause. To examine the possibility of GAD linkage with PDS, the authors performed genotype analyses of three families using polymorphic markers near the GAD genes (GAD1 and GAD2). In each family, the affected siblings exhibited different genotypes for the GAD2 gene; in two families the GAD1 genotype was disparate. These findings suggest that a mutation of GAD is not directly involved in all cases of PDS.
Duke Scholars
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
July 25, 2000
Volume
55
Issue
2
Start / End Page
309 / 311
Location
United States
Related Subject Headings
- Vitamin B 6 Deficiency
- Spasms, Infantile
- Pyridoxine
- Neurology & Neurosurgery
- Male
- Isoenzymes
- Infant, Newborn
- Infant
- Humans
- Glutamate Decarboxylase
Citation
APA
Chicago
ICMJE
MLA
NLM
Battaglioli, G., Rosen, D. R., Gospe, S. M., & Martin, D. L. (2000). Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures. Neurology, 55(2), 309–311. https://doi.org/10.1212/wnl.55.2.309
Battaglioli, G., D. R. Rosen, S. M. Gospe, and D. L. Martin. “Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.” Neurology 55, no. 2 (July 25, 2000): 309–11. https://doi.org/10.1212/wnl.55.2.309.
Battaglioli G, Rosen DR, Gospe SM, Martin DL. Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures. Neurology. 2000 Jul 25;55(2):309–11.
Battaglioli, G., et al. “Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures.” Neurology, vol. 55, no. 2, July 2000, pp. 309–11. Pubmed, doi:10.1212/wnl.55.2.309.
Battaglioli G, Rosen DR, Gospe SM, Martin DL. Glutamate decarboxylase is not genetically linked to pyridoxine-dependent seizures. Neurology. 2000 Jul 25;55(2):309–311.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
July 25, 2000
Volume
55
Issue
2
Start / End Page
309 / 311
Location
United States
Related Subject Headings
- Vitamin B 6 Deficiency
- Spasms, Infantile
- Pyridoxine
- Neurology & Neurosurgery
- Male
- Isoenzymes
- Infant, Newborn
- Infant
- Humans
- Glutamate Decarboxylase