Skip to main content
Journal cover image

Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.

Publication ,  Journal Article
deSouza, NM; Winfield, JM; Waterton, JC; Weller, A; Papoutsaki, M-V; Doran, SJ; Collins, DJ; Fournier, L; Sullivan, D; Chenevert, T; Jackson, A ...
Published in: Eur Radiol
March 2018

UNLABELLED: For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective assessment of images, whereas for prognosis, progression or response, quantitative evaluation of the apparent diffusion coefficient (ADC) is required. Validation and qualification of ADC in multicentre trials involves examination of i) technical performance to determine biomarker bias and reproducibility and ii) biological performance to interrogate a specific aspect of biology or to forecast outcome. Unfortunately, the variety of acquisition and analysis methodologies employed at different centres make ADC values non-comparable between them. This invalidates implementation in multicentre trials and limits utility of ADC as a biomarker. This article reviews the factors contributing to ADC variability in terms of data acquisition and analysis. Hardware and software considerations are discussed when implementing standardised protocols across multi-vendor platforms together with methods for quality assurance and quality control. Processes of data collection, archiving, curation, analysis, central reading and handling incidental findings are considered in the conduct of multicentre trials. Data protection and good clinical practice are essential prerequisites. Developing international consensus of procedures is critical to successful validation if ADC is to become a useful biomarker in oncology. KEY POINTS: • Standardised acquisition/analysis allows quantification of imaging biomarkers in multicentre trials. • Establishing "precision" of the measurement in the multicentre context is essential. • A repository with traceable data of known provenance promotes further research.

Duke Scholars

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

March 2018

Volume

28

Issue

3

Start / End Page

1118 / 1131

Location

Germany

Related Subject Headings

  • Software
  • Reproducibility of Results
  • Quality Assurance, Health Care
  • Prospective Studies
  • Prognosis
  • Nuclear Medicine & Medical Imaging
  • Neoplasms
  • Multicenter Studies as Topic
  • Humans
  • Healthy Volunteers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
deSouza, N. M., Winfield, J. M., Waterton, J. C., Weller, A., Papoutsaki, M.-V., Doran, S. J., … Liu, Y. (2018). Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. Eur Radiol, 28(3), 1118–1131. https://doi.org/10.1007/s00330-017-4972-z
deSouza, N. M., J. M. Winfield, J. C. Waterton, A. Weller, M. -. V. Papoutsaki, S. J. Doran, D. J. Collins, et al. “Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.Eur Radiol 28, no. 3 (March 2018): 1118–31. https://doi.org/10.1007/s00330-017-4972-z.
deSouza NM, Winfield JM, Waterton JC, Weller A, Papoutsaki M-V, Doran SJ, et al. Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. Eur Radiol. 2018 Mar;28(3):1118–31.
deSouza, N. M., et al. “Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.Eur Radiol, vol. 28, no. 3, Mar. 2018, pp. 1118–31. Pubmed, doi:10.1007/s00330-017-4972-z.
deSouza NM, Winfield JM, Waterton JC, Weller A, Papoutsaki M-V, Doran SJ, Collins DJ, Fournier L, Sullivan D, Chenevert T, Jackson A, Boss M, Trattnig S, Liu Y. Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives. Eur Radiol. 2018 Mar;28(3):1118–1131.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

March 2018

Volume

28

Issue

3

Start / End Page

1118 / 1131

Location

Germany

Related Subject Headings

  • Software
  • Reproducibility of Results
  • Quality Assurance, Health Care
  • Prospective Studies
  • Prognosis
  • Nuclear Medicine & Medical Imaging
  • Neoplasms
  • Multicenter Studies as Topic
  • Humans
  • Healthy Volunteers