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Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging.

Publication ,  Journal Article
Grewal, DS; Brar, GS; Jain, R; Sood, V; Singla, M; Grewal, SPS
Published in: J Cataract Refract Surg
March 2009

PURPOSE: To evaluate changes in corneal curvature, corneal elevation, corneal thickness, lens density, and foveal thickness after corneal collagen crosslinking with riboflavin and ultraviolet-A (UVA) light in eyes with progressive keratoconus. SETTING: Grewal Eye Institute, Chandigarh, India. METHODS: Subjective refraction, best corrected visual acuity (BCVA), Scheimpflug imaging, and optical coherence tomography were performed preoperatively and 1 week, 1, 3, and 6 months, and 1 year after crosslinking. RESULTS: There were no significant differences (P > 0.05) in mean values between preoperatively and 1 year postoperatively, respectively, in BCVA (0.22 +/- 0.10 and 0.20 +/- 0.10), spherical equivalent (-6.30 +/- 4.50 diopters (D) and -4.90 +/- 3.50 D), or cylinder vector (1.58 x 7( degrees ) +/- 3.8 D and 1.41 x 24( degrees ) +/- 3.5 D). There was no significant difference in mean measurements between preoperatively and 1 year postoperatively, respectively, for central corneal thickness (458.9 +/- 40 microm and 455.2 +/- 48.6 microm), anterior corneal curvature (50.6 +/- 7.4 D and 51.5 +/- 3.6 D), posterior corneal curvature (-7.7 +/- 1.2 D and -7.4 +/- 1.1 D), apex anterior (P = .9), posterior corneal elevation (P = .7), lens density (P = .33), or foveal thickness (175.7 +/- 35.6 microm and 146.4 +/- 8.5 microm; P = .1). CONCLUSIONS: Stable BCVA, spherical equivalent, anterior and posterior corneal curvatures, and corneal elevation 1 year after crosslinking indicate that keratoconus did not progress. Unchanged lens density and foveal thickness suggest that the lens and macula were not affected after UVA exposure during crosslinking.

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Published In

J Cataract Refract Surg

DOI

EISSN

1873-4502

Publication Date

March 2009

Volume

35

Issue

3

Start / End Page

425 / 432

Location

United States

Related Subject Headings

  • Young Adult
  • Visual Acuity
  • Ultraviolet Rays
  • Riboflavin
  • Refraction, Ocular
  • Photosensitizing Agents
  • Photography
  • Photochemotherapy
  • Ophthalmology & Optometry
  • Male
 

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Grewal, D. S., Brar, G. S., Jain, R., Sood, V., Singla, M., & Grewal, S. P. S. (2009). Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg, 35(3), 425–432. https://doi.org/10.1016/j.jcrs.2008.11.046
Grewal, Dilraj S., Gagandeep S. Brar, Rajeev Jain, Vardaan Sood, Mohit Singla, and Satinder Pal Singh Grewal. “Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging.J Cataract Refract Surg 35, no. 3 (March 2009): 425–32. https://doi.org/10.1016/j.jcrs.2008.11.046.
Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SPS. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg. 2009 Mar;35(3):425–32.
Grewal, Dilraj S., et al. “Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging.J Cataract Refract Surg, vol. 35, no. 3, Mar. 2009, pp. 425–32. Pubmed, doi:10.1016/j.jcrs.2008.11.046.
Grewal DS, Brar GS, Jain R, Sood V, Singla M, Grewal SPS. Corneal collagen crosslinking using riboflavin and ultraviolet-A light for keratoconus: one-year analysis using Scheimpflug imaging. J Cataract Refract Surg. 2009 Mar;35(3):425–432.
Journal cover image

Published In

J Cataract Refract Surg

DOI

EISSN

1873-4502

Publication Date

March 2009

Volume

35

Issue

3

Start / End Page

425 / 432

Location

United States

Related Subject Headings

  • Young Adult
  • Visual Acuity
  • Ultraviolet Rays
  • Riboflavin
  • Refraction, Ocular
  • Photosensitizing Agents
  • Photography
  • Photochemotherapy
  • Ophthalmology & Optometry
  • Male