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Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.

Publication ,  Journal Article
Troester, MA; Sun, X; Allott, EH; Geradts, J; Cohen, SM; Tse, C-K; Kirk, EL; Thorne, LB; Mathews, M; Li, Y; Hu, Z; Robinson, WR; Hoadley, KA ...
Published in: J Natl Cancer Inst
February 1, 2018

BACKGROUND: African American breast cancer patients have lower frequency of hormone receptor-positive (HR+)/human epidermal growth factor receptor 2 (HER2)-negative disease and higher subtype-specific mortality. Racial differences in molecular subtype within clinically defined subgroups are not well understood. METHODS: Using data and biospecimens from the population-based Carolina Breast Cancer Study (CBCS) Phase 3 (2008-2013), we classified 980 invasive breast cancers using RNA expression-based PAM50 subtype and recurrence (ROR) score that reflects proliferation and tumor size. Molecular subtypes (Luminal A, Luminal B, HER2-enriched, and Basal-like) and ROR scores (high vs low/medium) were compared by race (blacks vs whites) and age (≤50 years vs > 50 years) using chi-square tests and analysis of variance tests. RESULTS: Black women of all ages had a statistically significantly lower frequency of Luminal A breast cancer (25.4% and 33.6% in blacks vs 42.8% and 52.1% in whites; younger and older, respectively). All other subtype frequencies were higher in black women (case-only odds ratio [OR] = 3.11, 95% confidence interval [CI] = 2.22 to 4.37, for Basal-like; OR = 1.45, 95% CI = 1.02 to 2.06, for Luminal B; OR = 2.04, 95% CI = 1.33 to 3.13, for HER2-enriched). Among clinically HR+/HER2- cases, Luminal A subtype was less common and ROR scores were statistically significantly higher among black women. CONCLUSIONS: Multigene assays highlight racial disparities in tumor subtype distribution that persist even in clinically defined subgroups. Differences in tumor biology (eg, HER2-enriched status) may be targetable to reduce disparities among clinically ER+/HER2- cases.

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Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

February 1, 2018

Volume

110

Issue

2

Start / End Page

176 / 182

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Tumor Burden
  • Recurrence
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • RNA, Neoplasm
  • Oncology & Carcinogenesis
 

Citation

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Troester, M. A., Sun, X., Allott, E. H., Geradts, J., Cohen, S. M., Tse, C.-K., … Perou, C. M. (2018). Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. J Natl Cancer Inst, 110(2), 176–182. https://doi.org/10.1093/jnci/djx135
Troester, Melissa A., Xuezheng Sun, Emma H. Allott, Joseph Geradts, Stephanie M. Cohen, Chiu-Kit Tse, Erin L. Kirk, et al. “Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.J Natl Cancer Inst 110, no. 2 (February 1, 2018): 176–82. https://doi.org/10.1093/jnci/djx135.
Troester MA, Sun X, Allott EH, Geradts J, Cohen SM, Tse C-K, et al. Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. J Natl Cancer Inst. 2018 Feb 1;110(2):176–82.
Troester, Melissa A., et al. “Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study.J Natl Cancer Inst, vol. 110, no. 2, Feb. 2018, pp. 176–82. Pubmed, doi:10.1093/jnci/djx135.
Troester MA, Sun X, Allott EH, Geradts J, Cohen SM, Tse C-K, Kirk EL, Thorne LB, Mathews M, Li Y, Hu Z, Robinson WR, Hoadley KA, Olopade OI, Reeder-Hayes KE, Earp HS, Olshan AF, Carey LA, Perou CM. Racial Differences in PAM50 Subtypes in the Carolina Breast Cancer Study. J Natl Cancer Inst. 2018 Feb 1;110(2):176–182.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

February 1, 2018

Volume

110

Issue

2

Start / End Page

176 / 182

Location

United States

Related Subject Headings

  • Young Adult
  • White People
  • Tumor Burden
  • Recurrence
  • Receptors, Progesterone
  • Receptors, Estrogen
  • Receptor, erbB-2
  • Receptor, ErbB-2
  • RNA, Neoplasm
  • Oncology & Carcinogenesis