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Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction.

Publication ,  Journal Article
Belperio, J; Palmer, SM; Weigt, SS
Published in: Ann Am Thorac Soc
September 2017

Lung transplantation is now considered to be a therapeutic option for patients with advanced-stage lung diseases. Unfortunately, due to post-transplant complications, both infectious and noninfectious, it is only a treatment and not a cure. Infections (e.g., bacterial, viral, and fungal) in the immunosuppressed lung transplant recipient are a common cause of mortality post transplant. Infections have more recently been explored as factors contributing to the risk of chronic lung allograft dysfunction (CLAD). Each major class of infection-(1) bacterial (Staphylococcus aureus and Pseudomonas aeruginosa); (2) viral (cytomegalovirus and community-acquired respiratory viruses); and (3) fungal (Aspergillus)-has been associated with the development of CLAD. Mechanistically, the microbe seems to be interacting with the allograft cells, stimulating the induction of chemokines, which recruit recipient leukocytes to the graft. The recipient leukocyte interactions with the microbe further up-regulate chemokines, amplifying the influx of allograft-infiltrating mononuclear cells. These events can promote recipient leukocytes to interact with the allograft, triggering an alloresponse and graft dysfunction. Overall, interactions between the microbe-allograft-host immune system alters chemokine production, which, in part, plays a role in the pathobiology of CLAD and mortality due to CLAD.

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Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

September 2017

Volume

14

Issue

Supplement_3

Start / End Page

S242 / S246

Location

United States

Related Subject Headings

  • Primary Graft Dysfunction
  • Opportunistic Infections
  • Lung Transplantation
  • Humans
  • Host-Pathogen Interactions
  • Chemokines
  • Allografts
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Belperio, J., Palmer, S. M., & Weigt, S. S. (2017). Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc, 14(Supplement_3), S242–S246. https://doi.org/10.1513/AnnalsATS.201606-464MG
Belperio, John, Scott M. Palmer, and S Sam Weigt. “Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction.Ann Am Thorac Soc 14, no. Supplement_3 (September 2017): S242–46. https://doi.org/10.1513/AnnalsATS.201606-464MG.
Belperio J, Palmer SM, Weigt SS. Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S242–6.
Belperio, John, et al. “Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction.Ann Am Thorac Soc, vol. 14, no. Supplement_3, Sept. 2017, pp. S242–46. Pubmed, doi:10.1513/AnnalsATS.201606-464MG.
Belperio J, Palmer SM, Weigt SS. Host-Pathogen Interactions and Chronic Lung Allograft Dysfunction. Ann Am Thorac Soc. 2017 Sep;14(Supplement_3):S242–S246.

Published In

Ann Am Thorac Soc

DOI

EISSN

2325-6621

Publication Date

September 2017

Volume

14

Issue

Supplement_3

Start / End Page

S242 / S246

Location

United States

Related Subject Headings

  • Primary Graft Dysfunction
  • Opportunistic Infections
  • Lung Transplantation
  • Humans
  • Host-Pathogen Interactions
  • Chemokines
  • Allografts
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology