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Discordant risk: overweight and cardiometabolic risk in Chinese adults.

Publication ,  Journal Article
Gordon-Larsen, P; Adair, LS; Meigs, JB; Mayer-Davis, E; Herring, A; Yan, S-K; Zhang, B; Du, S; Popkin, BM
Published in: Obesity (Silver Spring, Md.)
January 2013

Recent US work identified "metabolically healthy overweight" and "metabolically at risk normal weight" individuals. Less is known for modernizing countries with recent increased obesity.Fasting blood samples, anthropometry and blood pressure from 8,233 adults aged 18-98 in the 2009 nationwide China Health and Nutrition Survey, were used to determine prevalence of overweight (Asian cut point, BMI ≥ 23 kg/m(2) ) and five risk factors (prediabetes/diabetes (hemoglobin A1c ≥ 5.7%) inflammation (high-sensitivity C-reactive protein (hsCRP) ≥ 3 mg/l), prehypertension/hypertension (Systolic blood pressure/diastolic blood pressure ≥ 130/85 mm Hg), high triglycerides (≥ 150 mg/dl), low high-density lipoprotein cholesterol (<40 (men)/ <50 mg/dl (women)). Sex-stratified, logistic, and multinomial logistic regression models estimated concurrent obesity and cardiometabolic risk, with and without abdominal obesity, adjusting for age, smoking, alcohol consumption, physical activity, urbanicity, and income.Irrespective of urbanicity, 78.3% of the sample had ≥ 1 elevated cardiometabolic risk factor (normal weight: 33.2% had ≥ 1 elevated risk factor; overweight: 5.7% had none). At the age of 18-30 years, 47.4% had no elevated risk factors, which dropped to 6% by the age 70, largely due to age-related increase in hypertension risk (18-30 years: 11%; >70 years: 73%). Abdominal obesity was highly predictive of metabolic risk, irrespective of overweight (e.g., "metabolically at risk overweight" relative to "metabolically healthy normal weight" (men: relative risk ratio (RRR) = 39.06; 95% confidence interval (CI): 23.47, 65.00; women: RRR = 22.26; 95% CI: 17.49, 28.33)).A large proportion of Chinese adults have metabolic abnormalities. High hypertension risk with age, underlies the low prevalence of metabolically healthy overweight. Screening for cardiometabolic-related outcomes dependent upon overweight will likely miss a large portion of the Chinese at risk population.

Duke Scholars

Published In

Obesity (Silver Spring, Md.)

DOI

EISSN

1930-739X

ISSN

1930-7381

Publication Date

January 2013

Volume

21

Issue

1

Start / End Page

E166 / E174

Related Subject Headings

  • Triglycerides
  • Sex Factors
  • Risk Factors
  • Reference Values
  • Overweight
  • Obesity, Abdominal
  • Obesity
  • Middle Aged
  • Male
  • Logistic Models
 

Citation

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ICMJE
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Gordon-Larsen, P., Adair, L. S., Meigs, J. B., Mayer-Davis, E., Herring, A., Yan, S.-K., … Popkin, B. M. (2013). Discordant risk: overweight and cardiometabolic risk in Chinese adults. Obesity (Silver Spring, Md.), 21(1), E166–E174. https://doi.org/10.1002/oby.20409
Gordon-Larsen, Penny, Linda S. Adair, James B. Meigs, Elizabeth Mayer-Davis, Amy Herring, Sheng-kai Yan, Bing Zhang, Shufa Du, and Barry M. Popkin. “Discordant risk: overweight and cardiometabolic risk in Chinese adults.Obesity (Silver Spring, Md.) 21, no. 1 (January 2013): E166–74. https://doi.org/10.1002/oby.20409.
Gordon-Larsen P, Adair LS, Meigs JB, Mayer-Davis E, Herring A, Yan S-K, et al. Discordant risk: overweight and cardiometabolic risk in Chinese adults. Obesity (Silver Spring, Md). 2013 Jan;21(1):E166–74.
Gordon-Larsen, Penny, et al. “Discordant risk: overweight and cardiometabolic risk in Chinese adults.Obesity (Silver Spring, Md.), vol. 21, no. 1, Jan. 2013, pp. E166–74. Epmc, doi:10.1002/oby.20409.
Gordon-Larsen P, Adair LS, Meigs JB, Mayer-Davis E, Herring A, Yan S-K, Zhang B, Du S, Popkin BM. Discordant risk: overweight and cardiometabolic risk in Chinese adults. Obesity (Silver Spring, Md). 2013 Jan;21(1):E166–E174.
Journal cover image

Published In

Obesity (Silver Spring, Md.)

DOI

EISSN

1930-739X

ISSN

1930-7381

Publication Date

January 2013

Volume

21

Issue

1

Start / End Page

E166 / E174

Related Subject Headings

  • Triglycerides
  • Sex Factors
  • Risk Factors
  • Reference Values
  • Overweight
  • Obesity, Abdominal
  • Obesity
  • Middle Aged
  • Male
  • Logistic Models