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Squamous Cell Carcinoma DNA Detection Using Ultrabright SERS Nanorattles and Magnetic Beads for Head and Neck Cancer Molecular Diagnostics.

Publication ,  Journal Article
Vohra, P; Ngo, HT; Lee, WT; Vo Dinh, T
Published in: Anal Methods
October 7, 2017

A rise in head and neck cancers in low and middle countries over recent years has prompted the need for low-cost, resource-efficient diagnostic technologies. Standard diagnosis with histopathology is often not feasible due to the low number of trained pathologists in these regions, resulting in delayed diagnosis and treatment. This study presents an alternative diagnostic method to standard histopathology. We developed a surface enhanced raman scattering (SERS) based method to distinguish squamous cell carcinoma from other cell lines. Using a "sandwich" method employing ultrabright SERA nanorattles and magnetic beads, we directly targeted specific nucleic acid markers of squamous cells. Our method was able to detect the presence of squamous cells with high sensitivity and specificity, supporting its potential for use as a diagnostic tool in head and neck fine needle aspirations (FNA).

Duke Scholars

Published In

Anal Methods

DOI

EISSN

1759-9679

Publication Date

October 7, 2017

Volume

9

Issue

37

Start / End Page

5550 / 5556

Location

England

Related Subject Headings

  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry
 

Citation

APA
Chicago
ICMJE
MLA
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Vohra, P., Ngo, H. T., Lee, W. T., & Vo Dinh, T. (2017). Squamous Cell Carcinoma DNA Detection Using Ultrabright SERS Nanorattles and Magnetic Beads for Head and Neck Cancer Molecular Diagnostics. Anal Methods, 9(37), 5550–5556. https://doi.org/10.1039/c7ay01913k
Vohra, P., H. T. Ngo, W. T. Lee, and T. Vo Dinh. “Squamous Cell Carcinoma DNA Detection Using Ultrabright SERS Nanorattles and Magnetic Beads for Head and Neck Cancer Molecular Diagnostics.Anal Methods 9, no. 37 (October 7, 2017): 5550–56. https://doi.org/10.1039/c7ay01913k.
Vohra, P., et al. “Squamous Cell Carcinoma DNA Detection Using Ultrabright SERS Nanorattles and Magnetic Beads for Head and Neck Cancer Molecular Diagnostics.Anal Methods, vol. 9, no. 37, Oct. 2017, pp. 5550–56. Pubmed, doi:10.1039/c7ay01913k.
Journal cover image

Published In

Anal Methods

DOI

EISSN

1759-9679

Publication Date

October 7, 2017

Volume

9

Issue

37

Start / End Page

5550 / 5556

Location

England

Related Subject Headings

  • 4004 Chemical engineering
  • 3401 Analytical chemistry
  • 0399 Other Chemical Sciences
  • 0301 Analytical Chemistry