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Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector.

Publication ,  Journal Article
Amsden, JJ; Herr, PJ; Landry, DMW; Kim, W; Vyas, R; Parker, CB; Kirley, MP; Keil, AD; Gilchrist, KH; Radauscher, EJ; Hall, SD; Carlson, JB ...
Published in: Journal of the American Society for Mass Spectrometry
February 2018

Despite many potential applications, miniature mass spectrometers have had limited adoption in the field due to the tradeoff between throughput and resolution that limits their performance relative to laboratory instruments. Recently, a solution to this tradeoff has been demonstrated by using spatially coded apertures in magnetic sector mass spectrometers, enabling throughput and signal-to-background improvements of greater than an order of magnitude with no loss of resolution. This paper describes a proof of concept demonstration of a cycloidal coded aperture miniature mass spectrometer (C-CAMMS) demonstrating use of spatially coded apertures in a cycloidal sector mass analyzer for the first time. C-CAMMS also incorporates a miniature carbon nanotube (CNT) field emission electron ionization source and a capacitive transimpedance amplifier (CTIA) ion array detector. Results confirm the cycloidal mass analyzer's compatibility with aperture coding. A >10× increase in throughput was achieved without loss of resolution compared with a single slit instrument. Several areas where additional improvement can be realized are identified. Graphical Abstract ᅟ.

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Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

February 2018

Volume

29

Issue

2

Start / End Page

360 / 372

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry
 

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Amsden, J. J., Herr, P. J., Landry, D. M. W., Kim, W., Vyas, R., Parker, C. B., … Glass, J. T. (2018). Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector. Journal of the American Society for Mass Spectrometry, 29(2), 360–372. https://doi.org/10.1007/s13361-017-1820-y
Amsden, Jason J., Philip J. Herr, David M. W. Landry, William Kim, Raul Vyas, Charles B. Parker, Matthew P. Kirley, et al. “Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector.Journal of the American Society for Mass Spectrometry 29, no. 2 (February 2018): 360–72. https://doi.org/10.1007/s13361-017-1820-y.
Amsden JJ, Herr PJ, Landry DMW, Kim W, Vyas R, Parker CB, et al. Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector. Journal of the American Society for Mass Spectrometry. 2018 Feb;29(2):360–72.
Amsden, Jason J., et al. “Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector.Journal of the American Society for Mass Spectrometry, vol. 29, no. 2, Feb. 2018, pp. 360–72. Epmc, doi:10.1007/s13361-017-1820-y.
Amsden JJ, Herr PJ, Landry DMW, Kim W, Vyas R, Parker CB, Kirley MP, Keil AD, Gilchrist KH, Radauscher EJ, Hall SD, Carlson JB, Baldasaro N, Stokes D, Di Dona ST, Russell ZE, Grego S, Edwards SJ, Sperline RP, Denton MB, Stoner BR, Gehm ME, Glass JT. Proof of Concept Coded Aperture Miniature Mass Spectrometer Using a Cycloidal Sector Mass Analyzer, a Carbon Nanotube (CNT) Field Emission Electron Ionization Source, and an Array Detector. Journal of the American Society for Mass Spectrometry. 2018 Feb;29(2):360–372.
Journal cover image

Published In

Journal of the American Society for Mass Spectrometry

DOI

EISSN

1879-1123

ISSN

1044-0305

Publication Date

February 2018

Volume

29

Issue

2

Start / End Page

360 / 372

Related Subject Headings

  • Analytical Chemistry
  • 3401 Analytical chemistry
  • 0306 Physical Chemistry (incl. Structural)
  • 0304 Medicinal and Biomolecular Chemistry
  • 0301 Analytical Chemistry