P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolates
Plasmodium falciparum resistance to the antifolates has arisen rapidly in Asia and South America, and threatens the usefulness of these drugs in Africa. In vitro resistance to the antifolates is determined by mutations in parasite dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS). The role of DHFR and DHPS mutations in therapeutic failure of antifolate antimalarials is less clear. This review summarizes molecular epidemiological surveys, studies of in vivo selection of mutant alleles by drug treatment, and prospective studies of the ability of mutation-specific assays to predict clinical outcomes, and discusses the potential use of these assays for surveillance of resistance. © 1998 Harcourt Brace & Co. Ltd All rights reserved.
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- Oncology & Carcinogenesis
- 3107 Microbiology
- 3101 Biochemistry and cell biology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1108 Medical Microbiology
- 0605 Microbiology
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Oncology & Carcinogenesis
- 3107 Microbiology
- 3101 Biochemistry and cell biology
- 1115 Pharmacology and Pharmaceutical Sciences
- 1108 Medical Microbiology
- 0605 Microbiology