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Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation.

Publication ,  Journal Article
Utevsky, AV; Smith, DV; Young, JS; Huettel, SA
Published in: eNeuro
September 2017

Large-scale functional networks, as identified through the coordinated activity of spatially distributed brain regions, have become central objects of study in neuroscience because of their contributions to many processing domains. Yet, it remains unclear how these domain-general networks interact with focal brain regions to coordinate thought and action. Here, we investigated how the default-mode network (DMN) and executive control network (ECN), two networks associated with goal-directed behavior, shape task performance through their coupling with other cortical regions several seconds in advance of behavior. We measured these networks' connectivity during an adaptation of the monetary incentive delay (MID) response-time task in which human participants viewed social and nonsocial images (i.e., pictures of faces and landscapes, respectively) while brain activity was measured using fMRI. We found that participants displayed slower reaction times (RTs) subsequent to social trials relative to nonsocial trials. To examine the neural mechanisms driving this subsequent-RT effect, we integrated independent components analysis (ICA) and a network-based psychophysiological interaction (nPPI) analysis; this allowed us to investigate task-related changes in network coupling that preceded the observed trial-to-trial variation in RT. Strikingly, when subjects viewed social rewards, an area of the fusiform gyrus (FG) consistent with the functionally-defined fusiform face area (FFA) exhibited increased coupling with the ECN (relative to the DMN), and the relative magnitude of coupling tracked the slowing of RT on the following trial. These results demonstrate how large-scale, domain-general networks can interact with focal, domain-specific cortical regions to orchestrate subsequent behavior.

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Published In

eNeuro

DOI

EISSN

2373-2822

ISSN

2373-2822

Publication Date

September 2017

Volume

4

Issue

5

Start / End Page

ENEURO.0084 / ENEU17.2017

Related Subject Headings

  • Young Adult
  • Temporal Lobe
  • Social Behavior
  • Reward
  • Reaction Time
  • Principal Component Analysis
  • Nerve Net
  • Motivation
  • Models, Neurological
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Utevsky, A. V., Smith, D. V., Young, J. S., & Huettel, S. A. (2017). Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. ENeuro, 4(5), ENEURO.0084-ENEU17.2017. https://doi.org/10.1523/eneuro.0084-17.2017
Utevsky, Amanda V., David V. Smith, Jacob S. Young, and Scott A. Huettel. “Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation.ENeuro 4, no. 5 (September 2017): ENEURO.0084-ENEU17.2017. https://doi.org/10.1523/eneuro.0084-17.2017.
Utevsky AV, Smith DV, Young JS, Huettel SA. Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. eNeuro. 2017 Sep;4(5):ENEURO.0084-ENEU17.2017.
Utevsky, Amanda V., et al. “Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation.ENeuro, vol. 4, no. 5, Sept. 2017, p. ENEURO.0084-ENEU17.2017. Epmc, doi:10.1523/eneuro.0084-17.2017.
Utevsky AV, Smith DV, Young JS, Huettel SA. Large-Scale Network Coupling with the Fusiform Cortex Facilitates Future Social Motivation. eNeuro. 2017 Sep;4(5):ENEURO.0084-ENEU17.2017.

Published In

eNeuro

DOI

EISSN

2373-2822

ISSN

2373-2822

Publication Date

September 2017

Volume

4

Issue

5

Start / End Page

ENEURO.0084 / ENEU17.2017

Related Subject Headings

  • Young Adult
  • Temporal Lobe
  • Social Behavior
  • Reward
  • Reaction Time
  • Principal Component Analysis
  • Nerve Net
  • Motivation
  • Models, Neurological
  • Male