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Transport of drugs from blood vessels to tumour tissue.

Publication ,  Journal Article
Dewhirst, MW; Secomb, TW
Published in: Nat Rev Cancer
December 2017

The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature and the transport properties of the drug as it moves through microvessel walls and in the extravascular tissue. The aim of this Review is to provide a broad, balanced perspective on the current understanding of drug transport to tumour cells and on the progress in developing methods to enhance drug delivery. First, the fundamental processes of solute transport in blood and tissue by convection and diffusion are reviewed, including the dependence of penetration distance from vessels into tissue on solute binding or uptake in tissue. The effects of the abnormal characteristics of tumour vasculature and extravascular tissue on these transport properties are then discussed. Finally, methods for overcoming limitations in drug transport and thereby achieving improved therapeutic results are surveyed.

Duke Scholars

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Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

December 2017

Volume

17

Issue

12

Start / End Page

738 / 750

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Blood Vessels
  • Biological Transport
  • Antineoplastic Agents
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences
 

Citation

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Dewhirst, M. W., & Secomb, T. W. (2017). Transport of drugs from blood vessels to tumour tissue. Nat Rev Cancer, 17(12), 738–750. https://doi.org/10.1038/nrc.2017.93
Dewhirst, Mark W., and Timothy W. Secomb. “Transport of drugs from blood vessels to tumour tissue.Nat Rev Cancer 17, no. 12 (December 2017): 738–50. https://doi.org/10.1038/nrc.2017.93.
Dewhirst MW, Secomb TW. Transport of drugs from blood vessels to tumour tissue. Nat Rev Cancer. 2017 Dec;17(12):738–50.
Dewhirst, Mark W., and Timothy W. Secomb. “Transport of drugs from blood vessels to tumour tissue.Nat Rev Cancer, vol. 17, no. 12, Dec. 2017, pp. 738–50. Pubmed, doi:10.1038/nrc.2017.93.
Dewhirst MW, Secomb TW. Transport of drugs from blood vessels to tumour tissue. Nat Rev Cancer. 2017 Dec;17(12):738–750.

Published In

Nat Rev Cancer

DOI

EISSN

1474-1768

Publication Date

December 2017

Volume

17

Issue

12

Start / End Page

738 / 750

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
  • Drug Delivery Systems
  • Blood Vessels
  • Biological Transport
  • Antineoplastic Agents
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 11 Medical and Health Sciences