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Cell Biology of Astrocyte-Synapse Interactions.

Publication ,  Journal Article
Allen, NJ; Eroglu, C
Published in: Neuron
November 1, 2017

Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development.

Duke Scholars

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

November 1, 2017

Volume

96

Issue

3

Start / End Page

697 / 708

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Nerve Net
  • Humans
  • Cell Communication
  • Astrocytes
  • Animals
  • 5202 Biological psychology
 

Citation

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Allen, N. J., & Eroglu, C. (2017). Cell Biology of Astrocyte-Synapse Interactions. Neuron, 96(3), 697–708. https://doi.org/10.1016/j.neuron.2017.09.056
Allen, Nicola J., and Cagla Eroglu. “Cell Biology of Astrocyte-Synapse Interactions.Neuron 96, no. 3 (November 1, 2017): 697–708. https://doi.org/10.1016/j.neuron.2017.09.056.
Allen NJ, Eroglu C. Cell Biology of Astrocyte-Synapse Interactions. Neuron. 2017 Nov 1;96(3):697–708.
Allen, Nicola J., and Cagla Eroglu. “Cell Biology of Astrocyte-Synapse Interactions.Neuron, vol. 96, no. 3, Nov. 2017, pp. 697–708. Pubmed, doi:10.1016/j.neuron.2017.09.056.
Allen NJ, Eroglu C. Cell Biology of Astrocyte-Synapse Interactions. Neuron. 2017 Nov 1;96(3):697–708.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

November 1, 2017

Volume

96

Issue

3

Start / End Page

697 / 708

Location

United States

Related Subject Headings

  • Synaptic Transmission
  • Synapses
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Nerve Net
  • Humans
  • Cell Communication
  • Astrocytes
  • Animals
  • 5202 Biological psychology