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Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design.

Publication ,  Journal Article
Gao, Y; Tian, W; Han, X; Gao, F
Published in: Front Med
December 2017

Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design.

Duke Scholars

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Published In

Front Med

DOI

EISSN

2095-0225

Publication Date

December 2017

Volume

11

Issue

4

Start / End Page

480 / 489

Location

China

Related Subject Headings

  • Superinfection
  • Immunity, Humoral
  • Humans
  • HIV-1
  • HIV Infections
  • Antibodies, Neutralizing
  • 1199 Other Medical and Health Sciences
  • 1103 Clinical Sciences
 

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Gao, Y., Tian, W., Han, X., & Gao, F. (2017). Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design. Front Med, 11(4), 480–489. https://doi.org/10.1007/s11684-017-0594-8
Gao, Yang, Wen Tian, Xiaoxu Han, and Feng Gao. “Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design.Front Med 11, no. 4 (December 2017): 480–89. https://doi.org/10.1007/s11684-017-0594-8.
Gao, Yang, et al. “Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design.Front Med, vol. 11, no. 4, Dec. 2017, pp. 480–89. Pubmed, doi:10.1007/s11684-017-0594-8.
Journal cover image

Published In

Front Med

DOI

EISSN

2095-0225

Publication Date

December 2017

Volume

11

Issue

4

Start / End Page

480 / 489

Location

China

Related Subject Headings

  • Superinfection
  • Immunity, Humoral
  • Humans
  • HIV-1
  • HIV Infections
  • Antibodies, Neutralizing
  • 1199 Other Medical and Health Sciences
  • 1103 Clinical Sciences