Skip to main content

Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors.

Publication ,  Journal Article
Butler, EN; Bensen, JT; Chen, M; Conway, K; Richardson, DB; Sun, X; Geradts, J; Olshan, AF; Troester, MA
Published in: Cancer Epidemiol Biomarkers Prev
January 2018

Background: Smoking is a possible risk factor for breast cancer and has been linked to increased risk of estrogen receptor-positive (ER+) disease in some epidemiologic studies. It is unknown whether smoking has quantitative effects on ER expression.Methods: We examined relationships between smoking and ER expression from tumors of 1,888 women diagnosed with invasive breast cancer from a population-based study in North Carolina. ER expression was characterized using binary (±) and continuous measures for ER protein, ESR1 mRNA, and a multigene luminal score (LS) that serves as a measure of estrogen signaling in breast tumors. We used logistic and linear regression models to estimate temporal and dose-dependent associations between smoking and ER measures.Results: The odds of ER+, ESR1+, and LS+ tumors among current smokers (at the time of diagnosis), those who smoked 20 or more years, and those who smoked within 5 years of diagnosis were nearly double those of nonsmokers. Quantitative levels of ESR1 were highest among current smokers compared with never smokers overall [mean (log2) = 9.2 vs. 8.7, P < 0.05] and among ER+ cases; however, we did not observe associations between smoking measures and continuous ER protein expression.Conclusions: In relationship to breast cancer diagnosis, recent smoking was associated with higher odds of the ER+, ESR1+, and LS+ subtype. Current smoking was associated with elevated ESR1 mRNA levels and an elevated LS, but not with altered ER protein.Impact: A multigene LS and single-gene ESR1 mRNA may capture tumor changes associated with smoking. Cancer Epidemiol Biomarkers Prev; 27(1); 67-74. ©2017 AACR.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 2018

Volume

27

Issue

1

Start / End Page

67 / 74

Location

United States

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Factors
  • Regression Analysis
  • RNA, Messenger
  • North Carolina
  • Middle Aged
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Butler, E. N., Bensen, J. T., Chen, M., Conway, K., Richardson, D. B., Sun, X., … Troester, M. A. (2018). Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors. Cancer Epidemiol Biomarkers Prev, 27(1), 67–74. https://doi.org/10.1158/1055-9965.EPI-17-0404
Butler, Eboneé N., Jeannette T. Bensen, Mengjie Chen, Kathleen Conway, David B. Richardson, Xuezheng Sun, Joseph Geradts, Andrew F. Olshan, and Melissa A. Troester. “Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors.Cancer Epidemiol Biomarkers Prev 27, no. 1 (January 2018): 67–74. https://doi.org/10.1158/1055-9965.EPI-17-0404.
Butler EN, Bensen JT, Chen M, Conway K, Richardson DB, Sun X, et al. Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors. Cancer Epidemiol Biomarkers Prev. 2018 Jan;27(1):67–74.
Butler, Eboneé N., et al. “Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors.Cancer Epidemiol Biomarkers Prev, vol. 27, no. 1, Jan. 2018, pp. 67–74. Pubmed, doi:10.1158/1055-9965.EPI-17-0404.
Butler EN, Bensen JT, Chen M, Conway K, Richardson DB, Sun X, Geradts J, Olshan AF, Troester MA. Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors. Cancer Epidemiol Biomarkers Prev. 2018 Jan;27(1):67–74.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

January 2018

Volume

27

Issue

1

Start / End Page

67 / 74

Location

United States

Related Subject Headings

  • Young Adult
  • Smoking
  • Risk Factors
  • Regression Analysis
  • RNA, Messenger
  • North Carolina
  • Middle Aged
  • Humans
  • Gene Expression Regulation, Neoplastic
  • Female