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Mechanical Stimulus-Induced Wthdrawal Behavior Increases Subsequent Pre-Stimulus Local Field Potential Power in the Rostral Anterior Cingulate Cortex in Unanesthetized Rats.

Publication ,  Journal Article
Shen, Z; Sun, J; Liu, B; Jiang, Y; Wu, Y; Wang, J; Shao, X; Fang, J
Published in: Med Sci Monit
March 2, 2017

BACKGROUND The rostral anterior cingulate cortex (rACC) is important in pain expectation. Previous studies demonstrated that mechanical stimulus-induced withdrawal behaviors are spinally-mediated nocifensive reflexes in rats, but it is not known whether pain expectation is influenced by withdrawal behaviors. MATERIAL AND METHODS We reanalyzed previous mechanosensitivity measurements of 244 rats measured 5 times in succession. To study neural oscillation in the rACC, 1 recording microwire array was surgically implanted. Then, we simultaneously recorded the local field potential (LFP) of the rACC over the course of multiple withdrawal behaviors in unanesthetized rats. RESULTS From our previous withdrawal behavioral data in 244 rats, we observed that the distributions of paw withdrawal thresholds (PWTs) were denser and more concentrated after the first withdrawal behavior. Compared to the first mechanical stimulus, increased neuronal synchrony and a stronger delta band component existed in each pre-stimulus LFP in the rACC during subsequent stimuli. CONCLUSIONS Pain expectation could be involved in withdrawal behaviors, which is related to increased total power and delta band power of the subsequent pre-stimulus LFPs in the rACC.

Published In

Med Sci Monit

DOI

EISSN

1643-3750

Publication Date

March 2, 2017

Volume

23

Start / End Page

1099 / 1105

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pain Perception
  • Pain
  • Male
  • Gyrus Cinguli
  • General Clinical Medicine
  • Cone-Beam Computed Tomography
  • Cognitive Science
  • Central Nervous System
 

Citation

APA
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ICMJE
MLA
NLM
Shen, Z., Sun, J., Liu, B., Jiang, Y., Wu, Y., Wang, J., … Fang, J. (2017). Mechanical Stimulus-Induced Wthdrawal Behavior Increases Subsequent Pre-Stimulus Local Field Potential Power in the Rostral Anterior Cingulate Cortex in Unanesthetized Rats. Med Sci Monit, 23, 1099–1105. https://doi.org/10.12659/msm.903292
Shen, Zui, Jing Sun, Boyi Liu, Yongliang Jiang, Yuanyuan Wu, Jialing Wang, Xiaomei Shao, and Jianqiao Fang. “Mechanical Stimulus-Induced Wthdrawal Behavior Increases Subsequent Pre-Stimulus Local Field Potential Power in the Rostral Anterior Cingulate Cortex in Unanesthetized Rats.Med Sci Monit 23 (March 2, 2017): 1099–1105. https://doi.org/10.12659/msm.903292.

Published In

Med Sci Monit

DOI

EISSN

1643-3750

Publication Date

March 2, 2017

Volume

23

Start / End Page

1099 / 1105

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pain Perception
  • Pain
  • Male
  • Gyrus Cinguli
  • General Clinical Medicine
  • Cone-Beam Computed Tomography
  • Cognitive Science
  • Central Nervous System