Skip to main content

Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.

Publication ,  Journal Article
Said, N; Elias, WJ; Raghavan, P; Cupino, A; Tustison, N; Frysinger, R; Patrie, J; Xin, W; Wintermark, M
Published in: J Neurosurg
October 2014

OBJECTIVES: The purpose of this study was to investigate whether diffusion tensor imaging (DTI) of the corticospinal tract (CST) is a reliable surrogate for intraoperative macrostimulation through the deep brain stimulation (DBS) leads. The authors hypothesized that the distance on MRI from the DBS lead to the CST as determined by DTI would correlate with intraoperative motor thresholds from macrostimulations through the same DBS lead. METHODS: The authors retrospectively reviewed pre- and postoperative MRI studies and intraoperative macrostimulation recordings in 17 patients with Parkinson disease (PD) treated by DBS stimulation. Preoperative DTI tractography of the CST was coregistered with postoperative MRI studies showing the position of the DBS leads. The shortest distance and the angle from each contact of each DBS lead to the CST was automatically calculated using software-based analysis. The distance measurements calculated for each contact were evaluated with respect to the intraoperative voltage thresholds that elicited a motor response at each contact. RESULTS: There was a nonsignificant trend for voltage thresholds to increase when the distances between the DBS leads and the CST increased. There was a significant correlation between the angle and the voltage, but the correlation was weak (coefficient of correlation [R] = 0.36). CONCLUSIONS: Caution needs to be exercised when using DTI tractography information to guide DBS lead placement in patients with PD. Further studies are needed to compare DTI tractography measurements with other approaches such as microelectrode recordings and conventional intraoperative MRI-guided placement of DBS leads.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

October 2014

Volume

121

Issue

4

Start / End Page

929 / 935

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pyramidal Tracts
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Intraoperative Care
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Said, N., Elias, W. J., Raghavan, P., Cupino, A., Tustison, N., Frysinger, R., … Wintermark, M. (2014). Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease. J Neurosurg, 121(4), 929–935. https://doi.org/10.3171/2014.6.JNS131673
Said, Nicholas, W Jeff Elias, Prashant Raghavan, Alan Cupino, Nicholas Tustison, Robert Frysinger, James Patrie, Wenjun Xin, and Max Wintermark. “Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.J Neurosurg 121, no. 4 (October 2014): 929–35. https://doi.org/10.3171/2014.6.JNS131673.
Said N, Elias WJ, Raghavan P, Cupino A, Tustison N, Frysinger R, et al. Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease. J Neurosurg. 2014 Oct;121(4):929–35.
Said, Nicholas, et al. “Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease.J Neurosurg, vol. 121, no. 4, Oct. 2014, pp. 929–35. Pubmed, doi:10.3171/2014.6.JNS131673.
Said N, Elias WJ, Raghavan P, Cupino A, Tustison N, Frysinger R, Patrie J, Xin W, Wintermark M. Correlation of diffusion tensor tractography and intraoperative macrostimulation during deep brain stimulation for Parkinson disease. J Neurosurg. 2014 Oct;121(4):929–935.

Published In

J Neurosurg

DOI

EISSN

1933-0693

Publication Date

October 2014

Volume

121

Issue

4

Start / End Page

929 / 935

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Pyramidal Tracts
  • Parkinson Disease
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Intraoperative Care
  • Humans
  • Female