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SUMOylation in brain ischemia: Patterns, targets, and translational implications.

Publication ,  Journal Article
Bernstock, JD; Yang, W; Ye, DG; Shen, Y; Pluchino, S; Lee, Y-J; Hallenbeck, JM; Paschen, W
Published in: J Cereb Blood Flow Metab
January 2018

Post-translational protein modification by small ubiquitin-like modifier (SUMO) regulates a myriad of homeostatic and stress responses. The SUMOylation pathway has been extensively studied in brain ischemia. Convincing evidence is now at hand to support the notion that a major increase in levels of SUMOylated proteins is capable of inducing tolerance to ischemic stress. Therefore, the SUMOylation pathway has emerged as a promising therapeutic target for neuroprotection in the face of brain ischemia. Despite this, it is prudent to acknowledge that there are many key questions still to be addressed in brain ischemia related to SUMOylation. Accordingly, herein, we provide a critical review of literature within the field to summarize current knowledge and in so doing highlight pertinent translational implications of the SUMOylation pathway in brain ischemia.

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Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

January 2018

Volume

38

Issue

1

Start / End Page

5 / 16

Location

United States

Related Subject Headings

  • Sumoylation
  • Neuroprotection
  • Neurology & Neurosurgery
  • Humans
  • Brain Ischemia
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Bernstock, J. D., Yang, W., Ye, D. G., Shen, Y., Pluchino, S., Lee, Y.-J., … Paschen, W. (2018). SUMOylation in brain ischemia: Patterns, targets, and translational implications. J Cereb Blood Flow Metab, 38(1), 5–16. https://doi.org/10.1177/0271678X17742260
Bernstock, Joshua D., Wei Yang, Daniel G. Ye, Yuntian Shen, Stefano Pluchino, Yang-Ja Lee, John M. Hallenbeck, and Wulf Paschen. “SUMOylation in brain ischemia: Patterns, targets, and translational implications.J Cereb Blood Flow Metab 38, no. 1 (January 2018): 5–16. https://doi.org/10.1177/0271678X17742260.
Bernstock JD, Yang W, Ye DG, Shen Y, Pluchino S, Lee Y-J, et al. SUMOylation in brain ischemia: Patterns, targets, and translational implications. J Cereb Blood Flow Metab. 2018 Jan;38(1):5–16.
Bernstock, Joshua D., et al. “SUMOylation in brain ischemia: Patterns, targets, and translational implications.J Cereb Blood Flow Metab, vol. 38, no. 1, Jan. 2018, pp. 5–16. Pubmed, doi:10.1177/0271678X17742260.
Bernstock JD, Yang W, Ye DG, Shen Y, Pluchino S, Lee Y-J, Hallenbeck JM, Paschen W. SUMOylation in brain ischemia: Patterns, targets, and translational implications. J Cereb Blood Flow Metab. 2018 Jan;38(1):5–16.
Journal cover image

Published In

J Cereb Blood Flow Metab

DOI

EISSN

1559-7016

Publication Date

January 2018

Volume

38

Issue

1

Start / End Page

5 / 16

Location

United States

Related Subject Headings

  • Sumoylation
  • Neuroprotection
  • Neurology & Neurosurgery
  • Humans
  • Brain Ischemia
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology