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Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.

Publication ,  Journal Article
Salehi, M; Gastaldelli, A; D'Alessio, DA
Published in: Diabetes Obes Metab
April 2018

AIMS: Patients who have undergone Roux-en-Y gastric bypass surgery (GB) have exaggerated postprandial insulin secretion, which has been attributed to increased meal glucose appearance and enhanced incretin effect. Here, we sought to determine β-cell glucose sensitivity in the absence of meal stimulation and insulinotropic gut factors. MATERIALS AND METHODS: A total of 12 non-diabetic subjects with prior GB, and 7 matched non-surgical control subjects with normal glucose tolerance were studied. Blood glucose and insulin secretion rates were measured during a graded glucose infusion at increasing and then decreasing rates. Insulin sensitivity (SI ) and glucose effectiveness (SG ) were determined by the minimal model. RESULTS: GB subjects had SI comparable to that of control subjects. GB subjects had relative hyperglycaemia during the highest dose of glucose infusion associated with significantly reduced β-cell glucose sensitivity throughout both step-up (GB: 34 ± 6, CN: 82 ± 9 pmol min-1 mM-1 L, P < .0001) and step-down (GB: 31 ± 6, CN: 74 ± 9 pmol min-1 mM-1 L, P < .0001) phases of the glucose infusion. GB subjects also had reduced SG (GB: 0.04 ± 0.00, CN: 0.07 ± 0.01 min-1 , P = .004). CONCLUSION: In the absence of enteric stimuli, β-cell sensitivity to changes in glycaemia is blunted among individuals with GB, indicating a significant shift in a fundamental property of β-cell function several years after surgery.

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Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

April 2018

Volume

20

Issue

4

Start / End Page

872 / 878

Location

England

Related Subject Headings

  • Postprandial Period
  • Obesity
  • Middle Aged
  • Male
  • Insulin-Secreting Cells
  • Insulin Resistance
  • Insulin
  • Humans
  • Glucose
  • Gastric Bypass
 

Citation

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Salehi, M., Gastaldelli, A., & D’Alessio, D. A. (2018). Beta-cell sensitivity to glucose is impaired after gastric bypass surgery. Diabetes Obes Metab, 20(4), 872–878. https://doi.org/10.1111/dom.13165
Salehi, Marzieh, Amalia Gastaldelli, and David A. D’Alessio. “Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.Diabetes Obes Metab 20, no. 4 (April 2018): 872–78. https://doi.org/10.1111/dom.13165.
Salehi M, Gastaldelli A, D’Alessio DA. Beta-cell sensitivity to glucose is impaired after gastric bypass surgery. Diabetes Obes Metab. 2018 Apr;20(4):872–8.
Salehi, Marzieh, et al. “Beta-cell sensitivity to glucose is impaired after gastric bypass surgery.Diabetes Obes Metab, vol. 20, no. 4, Apr. 2018, pp. 872–78. Pubmed, doi:10.1111/dom.13165.
Salehi M, Gastaldelli A, D’Alessio DA. Beta-cell sensitivity to glucose is impaired after gastric bypass surgery. Diabetes Obes Metab. 2018 Apr;20(4):872–878.
Journal cover image

Published In

Diabetes Obes Metab

DOI

EISSN

1463-1326

Publication Date

April 2018

Volume

20

Issue

4

Start / End Page

872 / 878

Location

England

Related Subject Headings

  • Postprandial Period
  • Obesity
  • Middle Aged
  • Male
  • Insulin-Secreting Cells
  • Insulin Resistance
  • Insulin
  • Humans
  • Glucose
  • Gastric Bypass