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Molecular biology of head and neck cancer: risks and pathways.

Publication ,  Journal Article
Stadler, ME; Patel, MR; Couch, ME; Hayes, DN
Published in: Hematol Oncol Clin North Am
December 2008

Patients present with a differential baseline risk of cancer based on normal and expected variations in genes associated with cancer. The baseline risk of developing cancer is acted on throughout life as the genome of different cells interacts with the environment in the form of exposures (eg, toxins, infections). As genetic damage is incurred throughout a lifetime (directly to DNA sequences or to the epigenome), events are set in motion to progressively disrupt normal cellular pathways toward tumorigenesis. This article attempts to characterize broad categories of genetic aberrations and pathways in a manner that might be useful for the clinician to understand the risk of developing cancer, the pathways that are disrupted, and the potential for molecular-based diagnostics.

Duke Scholars

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

December 2008

Volume

22

Issue

6

Start / End Page

1099 / vii

Location

United States

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Neoplasms, Squamous Cell
  • Humans
  • Head and Neck Neoplasms
  • Epigenesis, Genetic
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stadler, M. E., Patel, M. R., Couch, M. E., & Hayes, D. N. (2008). Molecular biology of head and neck cancer: risks and pathways. Hematol Oncol Clin North Am, 22(6), 1099–vii. https://doi.org/10.1016/j.hoc.2008.08.007
Stadler, Michael E., Mihir R. Patel, Marion E. Couch, and David Neil Hayes. “Molecular biology of head and neck cancer: risks and pathways.Hematol Oncol Clin North Am 22, no. 6 (December 2008): 1099–vii. https://doi.org/10.1016/j.hoc.2008.08.007.
Stadler ME, Patel MR, Couch ME, Hayes DN. Molecular biology of head and neck cancer: risks and pathways. Hematol Oncol Clin North Am. 2008 Dec;22(6):1099–vii.
Stadler, Michael E., et al. “Molecular biology of head and neck cancer: risks and pathways.Hematol Oncol Clin North Am, vol. 22, no. 6, Dec. 2008, pp. 1099–vii. Pubmed, doi:10.1016/j.hoc.2008.08.007.
Stadler ME, Patel MR, Couch ME, Hayes DN. Molecular biology of head and neck cancer: risks and pathways. Hematol Oncol Clin North Am. 2008 Dec;22(6):1099–vii.
Journal cover image

Published In

Hematol Oncol Clin North Am

DOI

ISSN

0889-8588

Publication Date

December 2008

Volume

22

Issue

6

Start / End Page

1099 / vii

Location

United States

Related Subject Headings

  • Risk Factors
  • Oncology & Carcinogenesis
  • Neoplasms, Squamous Cell
  • Humans
  • Head and Neck Neoplasms
  • Epigenesis, Genetic
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology