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Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors.

Publication ,  Journal Article
Pinheiro, LC; Samuel, CA; Reeder-Hayes, KE; Wheeler, SB; Olshan, AF; Reeve, BB
Published in: Breast Cancer Res Treat
October 2016

PURPOSE: Although racial disparities in health-related quality of life (HRQOL) among women with breast cancer (BC) are well documented, less is known about HRQOL changes over time among women of different races. Our objective was to assess racial differences in HRQOL during active treatment and survivorship phases of BC care. METHODS: We used data from the third phase of the Carolina Breast Cancer Study (CBCS-III). CBCS-III enrolled 3000 women in North Carolina aged 20-74 years diagnosed with BC between 2008 and 2013. HRQOL assessments occurred 5 and 25 months post diagnosis, representing distinct phases of care. HRQOL measures included the Functional Assessment of Cancer Therapy for BC and Functional Assessment of Chronic Illness Therapy for Spiritual Well-Being. Analysis of covariance models were employed to assess racial differences in changes in HRQOL. RESULTS: The cohort included 2142 Non-Hispanic White (n = 1105) and Black women (n = 1037) who completed both HRQOL assessments. During active treatment, Whites reported physical and functional scores 2-2.5 points higher than Blacks (p < 0.0001). Spiritual HRQOL was 2.1 points higher for Blacks (p < 0.0001). During survivorship, differences persisted. After adjusting for demographic, socioeconomic, tumor, and treatment characteristics, physical and functional HRQOL gaps narrowed, but spiritual HRQOL gaps widened. CONCLUSIONS: Racial differences in physical and functional HRQOL during active treatment and survivorship may be largely mediated by socioeconomic factors. However, our results suggest that among Black women, spiritual HRQOL is well supported throughout the BC care continuum. These results inform opportunities for improving the quality and equity of supportive services for women with BC.

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Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

October 2016

Volume

159

Issue

3

Start / End Page

535 / 543

Location

Netherlands

Related Subject Headings

  • Young Adult
  • White People
  • Quality of Life
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Humans
  • Female
  • Cohort Studies
  • Cancer Survivors
 

Citation

APA
Chicago
ICMJE
MLA
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Pinheiro, L. C., Samuel, C. A., Reeder-Hayes, K. E., Wheeler, S. B., Olshan, A. F., & Reeve, B. B. (2016). Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors. Breast Cancer Res Treat, 159(3), 535–543. https://doi.org/10.1007/s10549-016-3965-y
Pinheiro, Laura C., Cleo A. Samuel, Katherine E. Reeder-Hayes, Stephanie B. Wheeler, Andrew F. Olshan, and Bryce B. Reeve. “Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors.Breast Cancer Res Treat 159, no. 3 (October 2016): 535–43. https://doi.org/10.1007/s10549-016-3965-y.
Pinheiro LC, Samuel CA, Reeder-Hayes KE, Wheeler SB, Olshan AF, Reeve BB. Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors. Breast Cancer Res Treat. 2016 Oct;159(3):535–43.
Pinheiro, Laura C., et al. “Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors.Breast Cancer Res Treat, vol. 159, no. 3, Oct. 2016, pp. 535–43. Pubmed, doi:10.1007/s10549-016-3965-y.
Pinheiro LC, Samuel CA, Reeder-Hayes KE, Wheeler SB, Olshan AF, Reeve BB. Understanding racial differences in health-related quality of life in a population-based cohort of breast cancer survivors. Breast Cancer Res Treat. 2016 Oct;159(3):535–543.
Journal cover image

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

October 2016

Volume

159

Issue

3

Start / End Page

535 / 543

Location

Netherlands

Related Subject Headings

  • Young Adult
  • White People
  • Quality of Life
  • Oncology & Carcinogenesis
  • North Carolina
  • Middle Aged
  • Humans
  • Female
  • Cohort Studies
  • Cancer Survivors