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Factors that impact health-related quality of life over time for individuals with head and neck cancer.

Publication ,  Journal Article
Reeve, BB; Cai, J; Zhang, H; Weissler, MC; Wisniewski, K; Gross, H; Olshan, AF
Published in: Laryngoscope
December 2016

OBJECTIVES/HYPOTHESIS: To identify sociodemographic, behavioral, and clinical factors associated with health-related quality of life (HRQOL) for head and neck cancer (HNC) patients over time. STUDY DESIGN: A population-based longitudinal cohort study. METHODS: Newly diagnosed HNC patients (N = 587) were administered the Functional Assessment of Cancer Therapy-Head and Neck questionnaire at baseline (median 3 months postdiagnosis) and two follow-up assessments (median 22 and 42 months). Linear mixed-effect models were used with backward variable selection to identify factors associated with HRQOL over time (P < .05). Adjusted means reported at 2 years postdiagnosis. RESULTS: African Americans reported better Functional Well-Being than whites (mean of 20.01 vs. 18.53) and fewer HNC symptoms over time. Older patients (75+ years) reported better HRQOL than younger patients (< 50 years). Current tobacco use compared to no tobacco use had worse Physical (20.20 vs. 21.50), Emotional (17.55 vs. 19.06), Social (21.28 vs. 22.88), and Functional (17.32 vs. 19.29) Well-Being and more HNC symptoms (21.50 vs. 23.71). Radiation therapy was associated with worse Physical and Functional Well-Being and more head and neck symptoms over time, but HRQOL was similar to those who were not irradiated by 2 to 4 years postdiagnosis. CONCLUSION: This study identified key factors for individuals at risk for poorer HRQOL that may help clinicians and caregivers find solutions to address these decrements. Smoking cessation programs can be encouraged for survivors who use tobacco. Psychological and social support and medications may help for dealing with emotional distress and dealing with the physical symptoms from treatment. LEVEL OF EVIDENCE: 4. Laryngoscope, 126:2718-2725, 2016.

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Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

December 2016

Volume

126

Issue

12

Start / End Page

2718 / 2725

Location

United States

Related Subject Headings

  • White People
  • Survivors
  • Surveys and Questionnaires
  • Socioeconomic Factors
  • Quality of Life
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
 

Citation

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ICMJE
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Reeve, B. B., Cai, J., Zhang, H., Weissler, M. C., Wisniewski, K., Gross, H., & Olshan, A. F. (2016). Factors that impact health-related quality of life over time for individuals with head and neck cancer. Laryngoscope, 126(12), 2718–2725. https://doi.org/10.1002/lary.26073
Reeve, Bryce B., Jianwen Cai, Hongtao Zhang, Mark C. Weissler, Kathy Wisniewski, Heather Gross, and Andrew F. Olshan. “Factors that impact health-related quality of life over time for individuals with head and neck cancer.Laryngoscope 126, no. 12 (December 2016): 2718–25. https://doi.org/10.1002/lary.26073.
Reeve BB, Cai J, Zhang H, Weissler MC, Wisniewski K, Gross H, et al. Factors that impact health-related quality of life over time for individuals with head and neck cancer. Laryngoscope. 2016 Dec;126(12):2718–25.
Reeve, Bryce B., et al. “Factors that impact health-related quality of life over time for individuals with head and neck cancer.Laryngoscope, vol. 126, no. 12, Dec. 2016, pp. 2718–25. Pubmed, doi:10.1002/lary.26073.
Reeve BB, Cai J, Zhang H, Weissler MC, Wisniewski K, Gross H, Olshan AF. Factors that impact health-related quality of life over time for individuals with head and neck cancer. Laryngoscope. 2016 Dec;126(12):2718–2725.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

Publication Date

December 2016

Volume

126

Issue

12

Start / End Page

2718 / 2725

Location

United States

Related Subject Headings

  • White People
  • Survivors
  • Surveys and Questionnaires
  • Socioeconomic Factors
  • Quality of Life
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans