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Impact of colorectal cancer diagnosis and treatment on health-related quality of life among older Americans: a population-based, case-control study.

Publication ,  Journal Article
Quach, C; Sanoff, HK; Williams, GR; Lyons, JC; Reeve, BB
Published in: Cancer
March 15, 2015

BACKGROUND: Data on health-related quality of life (HRQoL) changes among Americans aged ≥65 following colorectal cancer (CRC) diagnosis and treatment are limited. This study compared HRQoL changes among CRC patients across stages from before to after diagnosis with matched noncancer controls. METHODS: This population-based study used the Surveillance, Epidemiology, and End Results Medicare Health Outcomes Survey (MHOS) data set (1998-2007). Medicare Advantage beneficiaries diagnosed with CRC between their baseline and follow-up MHOS (n = 349) were matched to noncancer controls (n = 1745) using propensity scores. Mixed-effects analysis of covariance models estimated changes in HRQoL (measured by the Medical Outcomes Study Short Form-36/Veterans RAND 12-item Survey) and the ability to perform 6 activities of daily living (ADLs) between baseline and follow-up. Logistic regression models estimated odds ratios for ADL impairments and major depressive disorder (MDD) risk. RESULTS: Mean time between CRC diagnosis and follow-up MHOS was 12.3 ± 9.8 months. Compared with controls, CRC patients had significantly lower scores in all physical and mental health domains at follow-up. The greatest decrements were observed in physical health and were largely driven by declines in the 6 months postdiagnosis and in stage III and IV patients. At follow-up, CRC patients had greater overall ADL impairment and difficulty with dressing, eating, and getting in/out of chairs. CRC patients, particularly stage IV patients, had greater odds of being at risk for MDD relative to controls. CONCLUSIONS: This study further underscores the adverse effects of CRC on physical health and the need to support older Americans' basic self-care needs, with attention to later-stage patients' increased debility.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 15, 2015

Volume

121

Issue

6

Start / End Page

943 / 950

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Quality of Life
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Female
  • Depression
  • Colorectal Neoplasms
  • Case-Control Studies
 

Citation

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ICMJE
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Quach, C., Sanoff, H. K., Williams, G. R., Lyons, J. C., & Reeve, B. B. (2015). Impact of colorectal cancer diagnosis and treatment on health-related quality of life among older Americans: a population-based, case-control study. Cancer, 121(6), 943–950. https://doi.org/10.1002/cncr.29125
Quach, Caroleen, Hanna K. Sanoff, Grant R. Williams, Jessica C. Lyons, and Bryce B. Reeve. “Impact of colorectal cancer diagnosis and treatment on health-related quality of life among older Americans: a population-based, case-control study.Cancer 121, no. 6 (March 15, 2015): 943–50. https://doi.org/10.1002/cncr.29125.
Quach, Caroleen, et al. “Impact of colorectal cancer diagnosis and treatment on health-related quality of life among older Americans: a population-based, case-control study.Cancer, vol. 121, no. 6, Mar. 2015, pp. 943–50. Pubmed, doi:10.1002/cncr.29125.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

March 15, 2015

Volume

121

Issue

6

Start / End Page

943 / 950

Location

United States

Related Subject Headings

  • United States
  • Surveys and Questionnaires
  • Quality of Life
  • Oncology & Carcinogenesis
  • Male
  • Humans
  • Female
  • Depression
  • Colorectal Neoplasms
  • Case-Control Studies