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Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial.

Publication ,  Journal Article
Ediebah, DE; Coens, C; Zikos, E; Quinten, C; Ringash, J; King, MT; Schmucker von Koch, J; Gotay, C; Greimel, E; Flechtner, H; Weis, J ...
Published in: Br J Cancer
May 13, 2014

BACKGROUND: Little is known about whether changes in health-related quality of life (HRQoL) scores from baseline during treatment also predict survival, which we aim to investigate in this study. METHODS: We analysed data from 391 advanced non-small-cell lung cancer (NSCLC) patients enrolled in the EORTC 08975 study, which compared palliative chemotherapy regimens. HRQoL was assessed at baseline and after each chemotherapy cycle using the EORTC QLQ-C30 and QLQ-LC13. The prognostic significance of HRQoL scores at baseline and their changes over time was assessed with Cox regression, after adjusting for clinical and socio-demographic variables. RESULTS: After controlling for covariates, every 10-point increase in baseline pain and dysphagia was associated with 11% and 12% increased risk of death with hazard ratios (HRs) of 1.11 and 1.12, respectively. Every 10-point improvement of physical function at baseline (HR=0.93) was associated with 7% lower risk of death. Every 10-point increase in pain (HR=1.08) was associated with 8% increased risk of death at cycle 1. Every 10-point increase in social function (HR=0.91) at cycle 2 was associated with 9% lower risk of death. CONCLUSIONS: Our findings suggest that changes in HRQoL scores from baseline during treatment, as measured on subscales of the EORTC QLQ-C30 and QLQ-LC13, are significant prognostic factors for survival.

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Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

May 13, 2014

Volume

110

Issue

10

Start / End Page

2427 / 2433

Location

England

Related Subject Headings

  • Survival Analysis
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Risk
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Palliative Care
  • Pain
 

Citation

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Ediebah, D. E., Coens, C., Zikos, E., Quinten, C., Ringash, J., King, M. T., … Bottomley, A. (2014). Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial. Br J Cancer, 110(10), 2427–2433. https://doi.org/10.1038/bjc.2014.208
Ediebah, D. E., C. Coens, E. Zikos, C. Quinten, J. Ringash, M. T. King, J. Schmucker von Koch, et al. “Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial.Br J Cancer 110, no. 10 (May 13, 2014): 2427–33. https://doi.org/10.1038/bjc.2014.208.
Ediebah DE, Coens C, Zikos E, Quinten C, Ringash J, King MT, et al. Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial. Br J Cancer. 2014 May 13;110(10):2427–33.
Ediebah, D. E., et al. “Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial.Br J Cancer, vol. 110, no. 10, May 2014, pp. 2427–33. Pubmed, doi:10.1038/bjc.2014.208.
Ediebah DE, Coens C, Zikos E, Quinten C, Ringash J, King MT, Schmucker von Koch J, Gotay C, Greimel E, Flechtner H, Weis J, Reeve BB, Smit EF, Taphoorn MJB, Bottomley A. Does change in health-related quality of life score predict survival? Analysis of EORTC 08975 lung cancer trial. Br J Cancer. 2014 May 13;110(10):2427–2433.

Published In

Br J Cancer

DOI

EISSN

1532-1827

Publication Date

May 13, 2014

Volume

110

Issue

10

Start / End Page

2427 / 2433

Location

England

Related Subject Headings

  • Survival Analysis
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Risk
  • Randomized Controlled Trials as Topic
  • Quality of Life
  • Proportional Hazards Models
  • Prognosis
  • Palliative Care
  • Pain