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Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy.

Publication ,  Journal Article
Potosky, AL; Reeve, BB; Clegg, LX; Hoffman, RM; Stephenson, RA; Albertsen, PC; Gilliland, FD; Stanford, JL
Published in: J Natl Cancer Inst
March 20, 2002

BACKGROUND: Many men diagnosed with clinically localized prostate cancer are initially treated conservatively, receiving neither surgery nor radiotherapy for the first year. Treatment patterns and quality-of-life outcomes have not been previously reported for a population-based sample of such men. METHODS: A population-based random sample of men (n = 661) from six geographic regions who had been newly diagnosed with clinically localized prostate cancer from 1994 through 1995 were followed for up to 1 year. Eligible subjects received neither surgery nor radiotherapy within 1 year of initial diagnosis. We assessed disease-specific and generic quality-of-life outcomes in men receiving androgen deprivation therapy (ADT) compared with men receiving no therapy. All statistical tests were two-sided. RESULTS: Two hundred and forty-five study patients received ADT and the remaining 416 patients received no therapy. Approximately two thirds of the patients (n = 159) receiving ADT had either baseline Gleason scores greater than six or serum prostate-specific antigen values above 20 ng/mL. Among men who were sexually potent before diagnosis (ADT = 88 patients; no therapy = 223 patients), 80% of those on ADT reported being impotent after 1 year compared with 30% of those receiving no treatment (P < .001). Patients receiving ADT reported more physical discomfort 1 year after diagnosis than did men who had received no therapy. However, patients receiving ADT, compared with those receiving no therapy, were more likely to be satisfied with their treatment decision (56% pleased versus 45.3%; P =.001). Patients on ADT also experienced a statistically significant decline in vitality, but not in physical function, after adjustment for the confounding factors (P =.05). CONCLUSION: ADT is a commonly used primary therapy for clinically localized prostate cancer. Therefore, men considering ADT as an initial treatment should be aware that sexual function and some aspects of physical well-being are likely to be affected in the first year following this treatment.

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Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

March 20, 2002

Volume

94

Issue

6

Start / End Page

430 / 437

Location

United States

Related Subject Headings

  • Sexual Behavior
  • Quality of Life
  • Prostatic Neoplasms
  • Patient Satisfaction
  • Orchiectomy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Health Status
 

Citation

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Potosky, A. L., Reeve, B. B., Clegg, L. X., Hoffman, R. M., Stephenson, R. A., Albertsen, P. C., … Stanford, J. L. (2002). Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy. J Natl Cancer Inst, 94(6), 430–437. https://doi.org/10.1093/jnci/94.6.430
Potosky, Arnold L., Bryce B. Reeve, Limin X. Clegg, Richard M. Hoffman, Robert A. Stephenson, Peter C. Albertsen, Frank D. Gilliland, and Janet L. Stanford. “Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy.J Natl Cancer Inst 94, no. 6 (March 20, 2002): 430–37. https://doi.org/10.1093/jnci/94.6.430.
Potosky AL, Reeve BB, Clegg LX, Hoffman RM, Stephenson RA, Albertsen PC, et al. Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy. J Natl Cancer Inst. 2002 Mar 20;94(6):430–7.
Potosky, Arnold L., et al. “Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy.J Natl Cancer Inst, vol. 94, no. 6, Mar. 2002, pp. 430–37. Pubmed, doi:10.1093/jnci/94.6.430.
Potosky AL, Reeve BB, Clegg LX, Hoffman RM, Stephenson RA, Albertsen PC, Gilliland FD, Stanford JL. Quality of life following localized prostate cancer treated initially with androgen deprivation therapy or no therapy. J Natl Cancer Inst. 2002 Mar 20;94(6):430–437.
Journal cover image

Published In

J Natl Cancer Inst

DOI

ISSN

0027-8874

Publication Date

March 20, 2002

Volume

94

Issue

6

Start / End Page

430 / 437

Location

United States

Related Subject Headings

  • Sexual Behavior
  • Quality of Life
  • Prostatic Neoplasms
  • Patient Satisfaction
  • Orchiectomy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Health Status