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Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings.

Publication ,  Journal Article
Barnosky, AR; Hoddy, KK; Unterman, TG; Varady, KA
Published in: Transl Res
October 2014

Intermittent fasting (IF) regimens have gained considerable popularity in recent years, as some people find these diets easier to follow than traditional calorie restriction (CR) approaches. IF involves restricting energy intake on 1-3 d/wk, and eating freely on the nonrestriction days. Alternate day fasting (ADF) is a subclass of IF, which consists of a "fast day" (75% energy restriction) alternating with a "feed day" (ad libitum food consumption). Recent findings suggest that IF and ADF are equally as effective as CR for weight loss and cardioprotection. What remains unclear, however, is whether IF/ADF elicits comparable improvements in diabetes risk indicators, when compared with CR. Accordingly, the goal of this review was to compare the effects of IF and ADF with daily CR on body weight, fasting glucose, fasting insulin, and insulin sensitivity in overweight and obese adults. Results reveal superior decreases in body weight by CR vs IF/ADF regimens, yet comparable reductions in visceral fat mass, fasting insulin, and insulin resistance. None of the interventions produced clinically meaningful reductions in glucose concentrations. Taken together, these preliminary findings show promise for the use of IF and ADF as alternatives to CR for weight loss and type 2 diabetes risk reduction in overweight and obese populations, but more research is required before solid conclusions can be reached.

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Published In

Transl Res

DOI

EISSN

1878-1810

Publication Date

October 2014

Volume

164

Issue

4

Start / End Page

302 / 311

Location

United States

Related Subject Headings

  • Obesity
  • Humans
  • General Clinical Medicine
  • Fasting
  • Diet, Reducing
  • Diabetes Mellitus, Type 2
  • Caloric Restriction
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
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Barnosky, A. R., Hoddy, K. K., Unterman, T. G., & Varady, K. A. (2014). Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res, 164(4), 302–311. https://doi.org/10.1016/j.trsl.2014.05.013
Barnosky, Adrienne R., Kristin K. Hoddy, Terry G. Unterman, and Krista A. Varady. “Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings.Transl Res 164, no. 4 (October 2014): 302–11. https://doi.org/10.1016/j.trsl.2014.05.013.
Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res. 2014 Oct;164(4):302–11.
Barnosky, Adrienne R., et al. “Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings.Transl Res, vol. 164, no. 4, Oct. 2014, pp. 302–11. Pubmed, doi:10.1016/j.trsl.2014.05.013.
Barnosky AR, Hoddy KK, Unterman TG, Varady KA. Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res. 2014 Oct;164(4):302–311.
Journal cover image

Published In

Transl Res

DOI

EISSN

1878-1810

Publication Date

October 2014

Volume

164

Issue

4

Start / End Page

302 / 311

Location

United States

Related Subject Headings

  • Obesity
  • Humans
  • General Clinical Medicine
  • Fasting
  • Diet, Reducing
  • Diabetes Mellitus, Type 2
  • Caloric Restriction
  • 3202 Clinical sciences
  • 3101 Biochemistry and cell biology
  • 1103 Clinical Sciences