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Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center.

Publication ,  Journal Article
Furlong, M; Herring, AH; Goldman, BD; Daniels, JL; Wolff, MS; Engel, LS; Engel, SM
Published in: Child psychiatry and human development
August 2018

Neurodevelopmental outcomes including behavior, executive functioning, and IQ exhibit complex correlational structures, although they are often treated as independent in etiologic studies. We performed a principal components analysis of the behavioral assessment system for children, the behavior rating inventory of executive functioning, and the Wechsler scales of intelligence in a prospective birth cohort, and estimated associations with early life characteristics. We identified seven factors: (1) impulsivity and externalizing, (2) executive functioning, (3) internalizing, (4) perceptual reasoning, (5) adaptability, (6) processing speed, and (7) verbal intelligence. Prenatal fish consumption, maternal education, preterm birth, and the home environment were important predictors of various neurodevelopmental factors. Although maternal smoking was associated with more adverse externalizing, executive functioning, and adaptive composite scores in our sample, of the orthogonally-rotated factors, smoking was only associated with the impulsivity and externalizing factor ([Formula: see text] - 0.82, 95% CI - 1.42, - 0.23). These differences may be due to correlations among outcomes that were accounted for by using a phenotypic approach. Dimension reduction may improve upon traditional approaches by accounting for correlations among neurodevelopmental traits.

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Published In

Child psychiatry and human development

DOI

EISSN

1573-3327

ISSN

0009-398X

Publication Date

August 2018

Volume

49

Issue

4

Start / End Page

534 / 550

Related Subject Headings

  • Social Environment
  • Smoking
  • Prospective Studies
  • Prenatal Exposure Delayed Effects
  • Premature Birth
  • Pregnancy
  • Phenotype
  • Male
  • Intelligence
  • Infant
 

Citation

APA
Chicago
ICMJE
MLA
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Furlong, M., Herring, A. H., Goldman, B. D., Daniels, J. L., Wolff, M. S., Engel, L. S., & Engel, S. M. (2018). Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center. Child Psychiatry and Human Development, 49(4), 534–550. https://doi.org/10.1007/s10578-017-0773-5
Furlong, Melissa, Amy H. Herring, Barbara D. Goldman, Julie L. Daniels, Mary S. Wolff, Lawrence S. Engel, and Stephanie M. Engel. “Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center.Child Psychiatry and Human Development 49, no. 4 (August 2018): 534–50. https://doi.org/10.1007/s10578-017-0773-5.
Furlong M, Herring AH, Goldman BD, Daniels JL, Wolff MS, Engel LS, et al. Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center. Child psychiatry and human development. 2018 Aug;49(4):534–50.
Furlong, Melissa, et al. “Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center.Child Psychiatry and Human Development, vol. 49, no. 4, Aug. 2018, pp. 534–50. Epmc, doi:10.1007/s10578-017-0773-5.
Furlong M, Herring AH, Goldman BD, Daniels JL, Wolff MS, Engel LS, Engel SM. Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center. Child psychiatry and human development. 2018 Aug;49(4):534–550.
Journal cover image

Published In

Child psychiatry and human development

DOI

EISSN

1573-3327

ISSN

0009-398X

Publication Date

August 2018

Volume

49

Issue

4

Start / End Page

534 / 550

Related Subject Headings

  • Social Environment
  • Smoking
  • Prospective Studies
  • Prenatal Exposure Delayed Effects
  • Premature Birth
  • Pregnancy
  • Phenotype
  • Male
  • Intelligence
  • Infant