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Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways

Publication ,  Conference
Kastan, MB; Scarbrough, P; Chen, J; Brown, A; Crutchley, J; Fleenor, D
Published in: Molecular Cancer Research
April 1, 2017

The ATM protein kinase and p53 protein are both central mediators of many aspects of DNA damage and cellular stress signaling. While there is a clear, direct relationship between ATM and p53, ATM has numerous substrates in addition to p53 and, conversely, p53 can be activated by selected stresses without ATM. We have identified novel aspects of stress response signaling independently involving either ATM or p53. Though ATM plays a central role in mediating cellular responses to DNA breakage, some of the clinical abnormalities in the cancer-prone disorder, Ataxia-telangiectasia (A-T), are difficult to attribute directly to alterations in DNA damage signaling, such as neurodegeneration (primarily cerebellar), immunodeficiency, insulin resistance, progressive lung disease, and telangiectasia development. Our recent data demonstrate that, in addition to its DNA damage signaling functions, the ATM protein kinase has critical, p53-independent, non-canonical roles in modulating mitochondrial function and affecting metabolic stress signaling. It is intriguing that one gene product seems to be at a nexus of DNA damage signaling and metabolic signaling, but perhaps it should not be surprising that these pathways would be linked and that a protein with a PI-3K domain and a protein in the mTOR kinase family would provide such a link. These insights suggest that Ataxia-telangiectasia should be considered, at least in part, as a mitochondrial dysfunction disease and provide links between cancer-related DNA damage signaling, general metabolic signaling pathways, and cancer development. We have also identified novel aspects of p53 regulation by DNA damage involving ATM-independent regulation of RNA splicing, a process which affects splicing of p53 and other gene products and modulates cellular outcome after DNA damage. This DNA damage-induced alternative splicing pathway expands the repertoire of gene products that modulate cellular stress responses.Citation Format: Michael B. Kastan, Peter Scarbrough, Jing Chen, Adam Brown, John Crutchley, Donald Fleenor. Non-canonical aspects of ATM and p53 signaling pathways [abstract]. In: Proceedings of the AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; 2016 Nov 2-5; Montreal, QC, Canada. Philadelphia (PA): AACR; Mol Cancer Res 2017;15(4_Suppl):Abstract nr IA17.

Duke Scholars

Published In

Molecular Cancer Research

DOI

EISSN

1557-3125

ISSN

1541-7786

Publication Date

April 1, 2017

Volume

15

Issue

4_Supplement

Start / End Page

IA17 / IA17

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • Developmental Biology
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Kastan, M. B., Scarbrough, P., Chen, J., Brown, A., Crutchley, J., & Fleenor, D. (2017). Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways. In Molecular Cancer Research (Vol. 15, pp. IA17–IA17). American Association for Cancer Research (AACR). https://doi.org/10.1158/1557-3125.dnarepair16-ia17
Kastan, Michael B., Peter Scarbrough, Jing Chen, Adam Brown, John Crutchley, and Donald Fleenor. “Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways.” In Molecular Cancer Research, 15:IA17–IA17. American Association for Cancer Research (AACR), 2017. https://doi.org/10.1158/1557-3125.dnarepair16-ia17.
Kastan MB, Scarbrough P, Chen J, Brown A, Crutchley J, Fleenor D. Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways. In: Molecular Cancer Research. American Association for Cancer Research (AACR); 2017. p. IA17–IA17.
Kastan, Michael B., et al. “Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways.” Molecular Cancer Research, vol. 15, no. 4_Supplement, American Association for Cancer Research (AACR), 2017, pp. IA17–IA17. Crossref, doi:10.1158/1557-3125.dnarepair16-ia17.
Kastan MB, Scarbrough P, Chen J, Brown A, Crutchley J, Fleenor D. Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways. Molecular Cancer Research. American Association for Cancer Research (AACR); 2017. p. IA17–IA17.

Published In

Molecular Cancer Research

DOI

EISSN

1557-3125

ISSN

1541-7786

Publication Date

April 1, 2017

Volume

15

Issue

4_Supplement

Start / End Page

IA17 / IA17

Publisher

American Association for Cancer Research (AACR)

Related Subject Headings

  • Oncology & Carcinogenesis
  • Developmental Biology
  • 3211 Oncology and carcinogenesis
  • 3101 Biochemistry and cell biology
  • 1112 Oncology and Carcinogenesis