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Antifibrinolytic Therapy and Perioperative Considerations.

Publication ,  Journal Article
Levy, JH; Koster, A; Quinones, QJ; Milling, TJ; Key, NS
Published in: Anesthesiology
March 2018

Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are increasingly used to reduce bleeding, allogeneic blood administration, and adverse clinical outcomes. Tranexamic acid is the agent most extensively studied and used in most countries. This review will explore the role of fibrinolysis as a pathologic mechanism, review the different pharmacologic agents used to inhibit fibrinolysis, and focus on the role of tranexamic acid as a therapeutic agent to reduce bleeding in patients after surgery and trauma.

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Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

March 2018

Volume

128

Issue

3

Start / End Page

657 / 670

Location

United States

Related Subject Headings

  • Tranexamic Acid
  • Perioperative Care
  • Humans
  • Fibrinolysis
  • Blood Loss, Surgical
  • Blood Coagulation Disorders
  • Antifibrinolytic Agents
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Levy, J. H., Koster, A., Quinones, Q. J., Milling, T. J., & Key, N. S. (2018). Antifibrinolytic Therapy and Perioperative Considerations. Anesthesiology, 128(3), 657–670. https://doi.org/10.1097/ALN.0000000000001997
Levy, Jerrold H., Andreas Koster, Quintin J. Quinones, Truman J. Milling, and Nigel S. Key. “Antifibrinolytic Therapy and Perioperative Considerations.Anesthesiology 128, no. 3 (March 2018): 657–70. https://doi.org/10.1097/ALN.0000000000001997.
Levy JH, Koster A, Quinones QJ, Milling TJ, Key NS. Antifibrinolytic Therapy and Perioperative Considerations. Anesthesiology. 2018 Mar;128(3):657–70.
Levy, Jerrold H., et al. “Antifibrinolytic Therapy and Perioperative Considerations.Anesthesiology, vol. 128, no. 3, Mar. 2018, pp. 657–70. Pubmed, doi:10.1097/ALN.0000000000001997.
Levy JH, Koster A, Quinones QJ, Milling TJ, Key NS. Antifibrinolytic Therapy and Perioperative Considerations. Anesthesiology. 2018 Mar;128(3):657–670.

Published In

Anesthesiology

DOI

EISSN

1528-1175

Publication Date

March 2018

Volume

128

Issue

3

Start / End Page

657 / 670

Location

United States

Related Subject Headings

  • Tranexamic Acid
  • Perioperative Care
  • Humans
  • Fibrinolysis
  • Blood Loss, Surgical
  • Blood Coagulation Disorders
  • Antifibrinolytic Agents
  • Anesthesiology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences