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Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention.

Publication ,  Journal Article
Schrepf, A; Harte, SE; Miller, N; Fowler, C; Nay, C; Williams, DA; Clauw, DJ; Rothberg, A
Published in: The journal of pain
December 2017

Weight loss is known to improve pain localized to weight-bearing joints but it is not known how weight loss affects the spatial distribution of pain and associated somatic symptoms like fatigue. We sought to determine if weight loss using a low-calorie diet improves pain, affect, and somatic symptoms commonly associated with chronic pain conditions in an observational study. We also documented changes in inflammatory markers in serum before and after weight loss. Participants were 123 obese individuals undergoing a 12- to 16-week calorie restriction weight loss intervention. The spatial distribution of pain, symptom severity (eg, fatigue, sleep difficulties), depression, and total fibromyalgia scale scores were measured before and after weight loss. Pain (P = . 022), symptom severity (P = .004), depression (P < .001), and fibromyalgia scores (P = .004) improved after weight loss; men showed greater improvement than women on somatic symptoms and fibromyalgia scores (both P < .01). Those who lost at least 10% of body weight showed greater improvement than those who lost <10%. Levels of the regulatory cytokine interleukin-10 increased after the intervention (P = .002). Weight loss may improve diffuse pain and comorbid symptoms commonly seen in chronic pain participants.This article presents the effect of a weight loss intervention on characteristics of chronic pain, including the spatial distribution of pain and comorbid somatic symptoms. Weight loss appeared to produce larger improvements in somatic symptoms for men.

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Published In

The journal of pain

DOI

EISSN

1528-8447

ISSN

1526-5900

Publication Date

December 2017

Volume

18

Issue

12

Start / End Page

1542 / 1550

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Pain
  • Outcome Assessment, Health Care
  • Obesity
  • Middle Aged
  • Male
  • Leiomyoma
  • Interleukin-10
  • Inflammation
 

Citation

APA
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ICMJE
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Schrepf, A., Harte, S. E., Miller, N., Fowler, C., Nay, C., Williams, D. A., … Rothberg, A. (2017). Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. The Journal of Pain, 18(12), 1542–1550. https://doi.org/10.1016/j.jpain.2017.08.004
Schrepf, Andrew, Steven E. Harte, Nicole Miller, Christine Fowler, Catherine Nay, David A. Williams, Daniel J. Clauw, and Amy Rothberg. “Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention.The Journal of Pain 18, no. 12 (December 2017): 1542–50. https://doi.org/10.1016/j.jpain.2017.08.004.
Schrepf A, Harte SE, Miller N, Fowler C, Nay C, Williams DA, et al. Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. The journal of pain. 2017 Dec;18(12):1542–50.
Schrepf, Andrew, et al. “Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention.The Journal of Pain, vol. 18, no. 12, Dec. 2017, pp. 1542–50. Epmc, doi:10.1016/j.jpain.2017.08.004.
Schrepf A, Harte SE, Miller N, Fowler C, Nay C, Williams DA, Clauw DJ, Rothberg A. Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. The journal of pain. 2017 Dec;18(12):1542–1550.
Journal cover image

Published In

The journal of pain

DOI

EISSN

1528-8447

ISSN

1526-5900

Publication Date

December 2017

Volume

18

Issue

12

Start / End Page

1542 / 1550

Related Subject Headings

  • Young Adult
  • Weight Loss
  • Pain
  • Outcome Assessment, Health Care
  • Obesity
  • Middle Aged
  • Male
  • Leiomyoma
  • Interleukin-10
  • Inflammation