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The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women

Publication ,  Journal Article
Browning, DJ; Lee, C; Rotberg, D
Published in: Clinical Ophthalmology
July 24, 2014

Purpose: To determine how algorithms for ideal body weight (IBW) affect hydroxychloroquine dosing in women. Methods: This was a retrospective study of 520 patients screened for hydroxychloroquine retinopathy. Charts were reviewed for sex, height, weight, and daily dose. The outcome measures were ranges of IBW across algorithms; rates of potentially toxic dosing; height thresholds below which 400 mg/d dosing is potentially toxic; and rates for which actual body weight (ABW) was less than IBW. Results: Women made up 474 (91%) of the patients. The IBWs for a height varied from 30-34 pounds (13.6-15.5 kg) across algorithms. The threshold heights below which toxic dosing occurred varied from 62-70 inches (157.5-177.8 cm). Different algorithms placed 16%-98% of women in the toxic dosing range. The proportion for whom dosing should have been based on ABW rather than IBW ranged from 5%-31% across algorithms. Conclusion: Although hydroxychloroquine dosing should be based on the lesser of ABW and IBW, there is no consensus about the definition of IBW. The Michaelides algorithm is associated with the most frequent need to adjust dosing; the Metropolitan Life Insurance, large frame, mean value table with the least frequent need. No evidence indicates that one algorithm is superior to others. © 2014 Browning et al.

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Published In

Clinical Ophthalmology

DOI

EISSN

1177-5483

ISSN

1177-5467

Publication Date

July 24, 2014

Volume

8

Start / End Page

1401 / 1407

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry
 

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Browning, D. J., Lee, C., & Rotberg, D. (2014). The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women. Clinical Ophthalmology, 8, 1401–1407. https://doi.org/10.2147/OPTH.S66531
Browning, D. J., C. Lee, and D. Rotberg. “The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women.” Clinical Ophthalmology 8 (July 24, 2014): 1401–7. https://doi.org/10.2147/OPTH.S66531.
Browning DJ, Lee C, Rotberg D. The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women. Clinical Ophthalmology. 2014 Jul 24;8:1401–7.
Browning, D. J., et al. “The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women.” Clinical Ophthalmology, vol. 8, July 2014, pp. 1401–07. Scopus, doi:10.2147/OPTH.S66531.
Browning DJ, Lee C, Rotberg D. The impact of different algorithms for ideal body weight on screening for hydroxychloroquine retinopathy in women. Clinical Ophthalmology. 2014 Jul 24;8:1401–1407.

Published In

Clinical Ophthalmology

DOI

EISSN

1177-5483

ISSN

1177-5467

Publication Date

July 24, 2014

Volume

8

Start / End Page

1401 / 1407

Related Subject Headings

  • 3212 Ophthalmology and optometry
  • 1113 Opthalmology and Optometry