A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration.
Publication
, Journal Article
Nguyen, QD; Shah, SM; Browning, DJ; Hudson, H; Sonkin, P; Hariprasad, SM; Kaiser, P; Slakter, JS; Haller, J; Do, DV; Mieler, WF; Chu, K ...
Published in: Ophthalmology
November 2009
PURPOSE: To determine the safety, tolerability, maximum tolerated dose, and bioactivity of an intravitreal injection of vascular endothelial growth factor (VEGF) Trap-Eye, a fusion protein of binding domains from human VEGF receptors 1 and 2 with human immunoglobulin-G Fc that binds VEGF family members, in patients with neovascular age-related macular degeneration (AMD). DESIGN: Dose-escalation, multicenter, interventional clinical trial. PARTICIPANTS: Twenty-one patients (13 female, 8 male) with neovascular AMD (NVAMD) and lesions
Duke Scholars
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Published In
Ophthalmology
DOI
EISSN
1549-4713
Publication Date
November 2009
Volume
116
Issue
11
Start / End Page
2141 / 8.e1
Location
United States
Related Subject Headings
- Vitreous Body
- Visual Acuity
- Treatment Outcome
- Tomography, Optical Coherence
- Recombinant Fusion Proteins
- Receptors, Vascular Endothelial Growth Factor
- Ophthalmology & Optometry
- Maximum Tolerated Dose
- Male
- Macular Degeneration
Citation
APA
Chicago
ICMJE
MLA
NLM
Nguyen, Q. D., Shah, S. M., Browning, D. J., Hudson, H., Sonkin, P., Hariprasad, S. M., … Campochiaro, P. A. (2009). A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology, 116(11), 2141-8.e1. https://doi.org/10.1016/j.ophtha.2009.04.030
Nguyen, Quan Dong, Syed Mahmood Shah, David J. Browning, Henry Hudson, Peter Sonkin, Seenu M. Hariprasad, Peter Kaiser, et al. “A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration.” Ophthalmology 116, no. 11 (November 2009): 2141-8.e1. https://doi.org/10.1016/j.ophtha.2009.04.030.
Nguyen QD, Shah SM, Browning DJ, Hudson H, Sonkin P, Hariprasad SM, et al. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology. 2009 Nov;116(11):2141-8.e1.
Nguyen, Quan Dong, et al. “A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration.” Ophthalmology, vol. 116, no. 11, Nov. 2009, pp. 2141-8.e1. Pubmed, doi:10.1016/j.ophtha.2009.04.030.
Nguyen QD, Shah SM, Browning DJ, Hudson H, Sonkin P, Hariprasad SM, Kaiser P, Slakter JS, Haller J, Do DV, Mieler WF, Chu K, Yang K, Ingerman A, Vitti RL, Berliner AJ, Cedarbaum JM, Campochiaro PA. A phase I study of intravitreal vascular endothelial growth factor trap-eye in patients with neovascular age-related macular degeneration. Ophthalmology. 2009 Nov;116(11):2141–8.e1.
Published In
Ophthalmology
DOI
EISSN
1549-4713
Publication Date
November 2009
Volume
116
Issue
11
Start / End Page
2141 / 8.e1
Location
United States
Related Subject Headings
- Vitreous Body
- Visual Acuity
- Treatment Outcome
- Tomography, Optical Coherence
- Recombinant Fusion Proteins
- Receptors, Vascular Endothelial Growth Factor
- Ophthalmology & Optometry
- Maximum Tolerated Dose
- Male
- Macular Degeneration