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Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients.

Publication ,  Journal Article
Leraas, HJ; Kim, J; Sun, Z; Ezekian, B; Gulack, BC; Reed, CR; Tracy, ET
Published in: J Pediatr Hematol Oncol
May 2018

BACKGROUND: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor in children, with current evidence limited to single-center studies. We examined treatment and clinical outcomes for pediatric and adult SPN with a national data set. METHODS: The 2004 to 2013 National Cancer Data Base was queried to identify all patients diagnosed with SPN. The cohort was stratified by age (pediatric and adult) defined as below 18 years and 18 years and above, respectively. Baseline characteristics and unadjusted outcomes were compared. RESULTS: We identified 21 pediatric and 348 adult patients with SPN. Both groups displayed similar demographic composition. Patients were commonly female (90.5% [pediatric] vs. 85.9% [adult], P=0.56) and white (66.7% vs. 68.3%, P=0.74). Tumor location was similar between adults and children. Median tumor size was similar between children and adults (5.9 vs. 4.9 cm, P=0.41). Treatment strategies did not vary between groups. Partial pancreatectomy was the most common resection strategy (71.4% vs. 53.1%, P=0.80). Both groups experienced low mortality (0.0% vs. 0.7% at 5 y, P=0.31). CONCLUSIONS: This study provides the largest comparison of pediatric and adult SPN to date. Children with SPN have similar disease severity at presentation, receive similar treatments, and demonstrate equivalent postoperative outcomes compared with their adult counterparts.

Duke Scholars

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

May 2018

Volume

40

Issue

4

Start / End Page

e233 / e236

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Databases, Factual
  • Cohort Studies
  • Adult
  • Adolescent
 

Citation

APA
Chicago
ICMJE
MLA
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Leraas, H. J., Kim, J., Sun, Z., Ezekian, B., Gulack, B. C., Reed, C. R., & Tracy, E. T. (2018). Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients. J Pediatr Hematol Oncol, 40(4), e233–e236. https://doi.org/10.1097/MPH.0000000000001049
Leraas, Harold J., Jina Kim, Zhifei Sun, Brian Ezekian, Brian C. Gulack, Christopher R. Reed, and Elisabeth T. Tracy. “Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients.J Pediatr Hematol Oncol 40, no. 4 (May 2018): e233–36. https://doi.org/10.1097/MPH.0000000000001049.
Leraas HJ, Kim J, Sun Z, Ezekian B, Gulack BC, Reed CR, et al. Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients. J Pediatr Hematol Oncol. 2018 May;40(4):e233–6.
Leraas, Harold J., et al. “Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients.J Pediatr Hematol Oncol, vol. 40, no. 4, May 2018, pp. e233–36. Pubmed, doi:10.1097/MPH.0000000000001049.
Leraas HJ, Kim J, Sun Z, Ezekian B, Gulack BC, Reed CR, Tracy ET. Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adults: A National Study of 369 Patients. J Pediatr Hematol Oncol. 2018 May;40(4):e233–e236.

Published In

J Pediatr Hematol Oncol

DOI

EISSN

1536-3678

Publication Date

May 2018

Volume

40

Issue

4

Start / End Page

e233 / e236

Location

United States

Related Subject Headings

  • Pancreatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Female
  • Databases, Factual
  • Cohort Studies
  • Adult
  • Adolescent