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Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature.

Publication ,  Journal Article
Perrin, EM; O'Shea, TM; Skinner, AC; Bose, C; Allred, EN; Fichorova, RN; van der Burg, JW; Leviton, A
Published in: Pediatr Res
June 2018

BackgroundChildhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity.MethodsIn a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age.ResultsAmong children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14. Among children delivered for maternal or fetal indications (n=148), obesity was associated with elevated concentrations of seven proteins on the 14th postnatal day. In multivariable models in the spontaneous indications subsample, elevated IL-6 on day 1 predicted obesity (odds ratio: 2.9; 95% confidence limits: 1.2, 6.8), whereas elevated VCAM-1 on day 14 predicted overweight at 2 years of age (odds ratio: 2.3; 95% confidence limits: 1.2, 4.3).ConclusionsIn this cohort, neonatal systemic inflammation preceded the onset of obesity, suggesting that inflammation might contribute to the development of obesity.

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Published In

Pediatr Res

DOI

EISSN

1530-0447

Publication Date

June 2018

Volume

83

Issue

6

Start / End Page

1110 / 1119

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Cell Adhesion Molecule-1
  • Risk
  • Receptors, Tumor Necrosis Factor, Type I
  • Premature Birth
  • Pregnancy
  • Placenta
  • Pediatrics
  • Pediatric Obesity
  • Overweight
 

Citation

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Perrin, E. M., O’Shea, T. M., Skinner, A. C., Bose, C., Allred, E. N., Fichorova, R. N., … Leviton, A. (2018). Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatr Res, 83(6), 1110–1119. https://doi.org/10.1038/pr.2017.313
Perrin, Eliana M., T Michael O’Shea, Asheley Cockrell Skinner, Carl Bose, Elizabeth N. Allred, Raina N. Fichorova, Jelske W. van der Burg, and Alan Leviton. “Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature.Pediatr Res 83, no. 6 (June 2018): 1110–19. https://doi.org/10.1038/pr.2017.313.
Perrin EM, O’Shea TM, Skinner AC, Bose C, Allred EN, Fichorova RN, et al. Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatr Res. 2018 Jun;83(6):1110–9.
Perrin, Eliana M., et al. “Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature.Pediatr Res, vol. 83, no. 6, June 2018, pp. 1110–19. Pubmed, doi:10.1038/pr.2017.313.
Perrin EM, O’Shea TM, Skinner AC, Bose C, Allred EN, Fichorova RN, van der Burg JW, Leviton A. Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatr Res. 2018 Jun;83(6):1110–1119.

Published In

Pediatr Res

DOI

EISSN

1530-0447

Publication Date

June 2018

Volume

83

Issue

6

Start / End Page

1110 / 1119

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factor Receptor-1
  • Vascular Cell Adhesion Molecule-1
  • Risk
  • Receptors, Tumor Necrosis Factor, Type I
  • Premature Birth
  • Pregnancy
  • Placenta
  • Pediatrics
  • Pediatric Obesity
  • Overweight