Skip to main content

Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis.

Publication ,  Journal Article
Paul, TK; Bhatheja, S; Panchal, HB; Zheng, S; Banerjee, S; Rao, SV; Guzman, L; Beohar, N; Zhao, D; Mehran, R; Mukherjee, D
Published in: Circ Cardiovasc Interv
December 2017

BACKGROUND: Current guidelines give a class I recommendation to use of embolic protection devices (EPD) for saphenous vein graft (SVG) intervention; however, studies have shown conflicting results. The objective of this meta-analysis is to compare all-cause mortality, major adverse cardiovascular events, myocardial infarction (MI), or target vessel revascularization in SVG intervention with and without EPD. METHODS AND RESULTS: Literature was searched through October 2016. Eight studies (n=52 893) comparing SVG intervention performed with EPD (n=11 506) and without EPD (n=41 387) were included. There was no significant difference in all-cause mortality (odds ratio [OR], 0.79; confidence interval [CI], 0.55-1.12; P=0.19), major adverse cardiovascular events (OR, 0.73, CI, 0.51-1.05; P=0.09), target vessel revascularization (OR, 1.0; CI, 0.95-1.05; P=0.94), periprocedural MI (OR, 1.12; CI, 0.65-1.90, P=0.69), and late MI (OR, 0.80; CI, 0.52-1.23; P=0.30) between the 2 groups. Sensitivity analysis excluding CathPCI Registry study showed no difference in periprocedural MI, late MI, and target vessel revascularization; however, it favored EPD use in all-cause mortality and major adverse cardiovascular events. Further sensitivity analysis including only observational studies revealed no difference in all-cause mortality, major adverse cardiovascular events, target vessel revascularization, and late MI. Additional analysis after excluding CathPCI Registry study revealed no difference in outcomes. CONCLUSIONS: This study including 52 893 patients suggests no apparent benefit in routine use of EPD during SVG intervention in the contemporary real-world practice. Further randomized clinical trials are needed in current era to evaluate long-term outcomes in routine use of EPD, and meanwhile, current guideline recommendations on EPD use should be revisited.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Circ Cardiovasc Interv

DOI

EISSN

1941-7632

Publication Date

December 2017

Volume

10

Issue

12

Location

United States

Related Subject Headings

  • Unnecessary Procedures
  • Treatment Outcome
  • Time Factors
  • Saphenous Vein
  • Risk Factors
  • Prosthesis Design
  • Percutaneous Coronary Intervention
  • Odds Ratio
  • Myocardial Infarction
  • Middle Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Paul, T. K., Bhatheja, S., Panchal, H. B., Zheng, S., Banerjee, S., Rao, S. V., … Mukherjee, D. (2017). Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis. Circ Cardiovasc Interv, 10(12). https://doi.org/10.1161/CIRCINTERVENTIONS.117.005538
Paul, Timir K., Samit Bhatheja, Hemang B. Panchal, Shimin Zheng, Subhash Banerjee, Sunil V. Rao, Luis Guzman, et al. “Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis.Circ Cardiovasc Interv 10, no. 12 (December 2017). https://doi.org/10.1161/CIRCINTERVENTIONS.117.005538.
Paul TK, Bhatheja S, Panchal HB, Zheng S, Banerjee S, Rao SV, et al. Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis. Circ Cardiovasc Interv. 2017 Dec;10(12).
Paul, Timir K., et al. “Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis.Circ Cardiovasc Interv, vol. 10, no. 12, Dec. 2017. Pubmed, doi:10.1161/CIRCINTERVENTIONS.117.005538.
Paul TK, Bhatheja S, Panchal HB, Zheng S, Banerjee S, Rao SV, Guzman L, Beohar N, Zhao D, Mehran R, Mukherjee D. Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device: A Comprehensive Review and Meta-Analysis. Circ Cardiovasc Interv. 2017 Dec;10(12).

Published In

Circ Cardiovasc Interv

DOI

EISSN

1941-7632

Publication Date

December 2017

Volume

10

Issue

12

Location

United States

Related Subject Headings

  • Unnecessary Procedures
  • Treatment Outcome
  • Time Factors
  • Saphenous Vein
  • Risk Factors
  • Prosthesis Design
  • Percutaneous Coronary Intervention
  • Odds Ratio
  • Myocardial Infarction
  • Middle Aged