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Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.

Publication ,  Journal Article
Husain, AN; Colby, TV; Ordóñez, NG; Allen, TC; Attanoos, RL; Beasley, MB; Butnor, KJ; Chirieac, LR; Churg, AM; Dacic, S; Galateau-Sallé, F ...
Published in: Arch Pathol Lab Med
January 2018

CONTEXT: - Malignant mesothelioma (MM) is an uncommon tumor that can be difficult to diagnose. OBJECTIVE: - To provide updated, practical guidelines for the pathologic diagnosis of MM. DATA SOURCES: - Pathologists involved in the International Mesothelioma Interest Group and others with an interest and expertise in the field contributed to this update. Reference material included up-to-date, peer-reviewed publications and textbooks. CONCLUSIONS: - There was discussion and consensus opinion regarding guidelines for (1) distinguishing benign from malignant mesothelial proliferations (both epithelioid and spindle cell lesions), (2) cytologic diagnosis of MM, (3) recognition of the key histologic features of pleural and peritoneal MM, (4) use of histochemical and immunohistochemical stains in the diagnosis and differential diagnosis of MM, (5) differentiating epithelioid MM from various carcinomas (lung, breast, ovarian, and colonic adenocarcinomas, and squamous cell and renal cell carcinomas), (6) diagnosis of sarcomatoid MM, (7) use of molecular markers in the diagnosis of MM, (8) electron microscopy in the diagnosis of MM, and (9) some caveats and pitfalls in the diagnosis of MM. Immunohistochemical panels are integral to the diagnosis of MM, but the exact makeup of panels employed is dependent on the differential diagnosis and on the antibodies available in a given laboratory. Depending on the morphology, immunohistochemical panels should contain both positive and negative markers for mesothelial differentiation and for lesions considered in the differential diagnosis. Immunohistochemical markers should have either sensitivity or specificity greater than 80% for the lesions in question. Interpretation of positivity generally should take into account the localization of the stain (eg, nuclear versus cytoplasmic) and the percentage of cells staining (>10% is suggested for cytoplasmic and membranous markers). Selected molecular markers are now being used to distinguish benign from malignant mesothelial proliferations. These guidelines are meant to be a practical diagnostic reference for the pathologist; however, some new pathologic predictors of prognosis and response to therapy are also included.

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Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

January 2018

Volume

142

Issue

1

Start / End Page

89 / 108

Location

United States

Related Subject Headings

  • Public Opinion
  • Pathology
  • Mesothelioma
  • Lung Neoplasms
  • Lung
  • Immunohistochemistry
  • Humans
  • Diagnosis, Differential
  • Cytodiagnosis
  • Consensus
 

Citation

APA
Chicago
ICMJE
MLA
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Husain, A. N., Colby, T. V., Ordóñez, N. G., Allen, T. C., Attanoos, R. L., Beasley, M. B., … Wick, M. R. (2018). Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch Pathol Lab Med, 142(1), 89–108. https://doi.org/10.5858/arpa.2017-0124-RA
Husain, Aliya Noor, Thomas V. Colby, Nelson G. Ordóñez, Timothy Craig Allen, Richard Luther Attanoos, Mary Beth Beasley, Kelly Jo Butnor, et al. “Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.Arch Pathol Lab Med 142, no. 1 (January 2018): 89–108. https://doi.org/10.5858/arpa.2017-0124-RA.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, et al. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch Pathol Lab Med. 2018 Jan;142(1):89–108.
Husain, Aliya Noor, et al. “Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.Arch Pathol Lab Med, vol. 142, no. 1, Jan. 2018, pp. 89–108. Pubmed, doi:10.5858/arpa.2017-0124-RA.
Husain AN, Colby TV, Ordóñez NG, Allen TC, Attanoos RL, Beasley MB, Butnor KJ, Chirieac LR, Churg AM, Dacic S, Galateau-Sallé F, Gibbs A, Gown AM, Krausz T, Litzky LA, Marchevsky A, Nicholson AG, Roggli VL, Sharma AK, Travis WD, Walts AE, Wick MR. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch Pathol Lab Med. 2018 Jan;142(1):89–108.

Published In

Arch Pathol Lab Med

DOI

EISSN

1543-2165

Publication Date

January 2018

Volume

142

Issue

1

Start / End Page

89 / 108

Location

United States

Related Subject Headings

  • Public Opinion
  • Pathology
  • Mesothelioma
  • Lung Neoplasms
  • Lung
  • Immunohistochemistry
  • Humans
  • Diagnosis, Differential
  • Cytodiagnosis
  • Consensus